N-[(R)-1-hydroxymethyl-2-(1H-indol-3-yl)-ethyl]-2-isopropoxy-5-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-7-ylethynyl)-benzamide | 1033264-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-[(R)-1-hydroxymethyl-2-(1H-indol-3-yl)-ethyl]-2-isopropoxy-5-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-7-ylethynyl)-benzamide
• 英文别名: N-[(2R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl]-5-[2-(1-oxo-3,4-dihydro-2H-isoquinolin-7-yl)ethynyl]-2-propan-2-yloxybenzamide
• CAS: 1033264-06-0
• 化学式: C₃₂H₃₁N₃O₄
• 分子量: 521.616
• InChiKey: GGGOYZWXVHRSFR-RUZDIDTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  103
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• 1,2-Diarylacetylene Derivatives of Acyltryptophanols
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1932831A1

  公开（公告）日：2008-06-18

  The present invention relates to acyltryptophanols of the general formula I, in which Q, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及通式I的酰基色氨酸醇，其中Q、W、R1、R2、R3、R4、R5、R6、R7和R8的含义如描述中所定义。根据本发明的化合物是有效的FSH拮抗剂，可用于例如男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS
  申请人：Wortmann Lars

  公开号：US20080221195A1

  公开（公告）日：2008-09-11

  The present invention relates to acyltryptophanols of the general formula I, in which Q, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及一般式I的酰基色氨酸醇，其中Q，W，R1，R2，R3，R4，R5，R6，R7和R8的含义如描述中所定义。本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• [EN] 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS<br/>[FR] DÉRIVÉS 1,2-DIARYLACETYLENE D'ACYLTRYPTOPHANOLS
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2008071453A1

  公开（公告）日：2008-06-19

  [EN] The present invention relates to acyltryptophanols of the general formula (I) in which Q, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
  [FR] Acyltryptophanols de formule générale (I), dans laquelle Q, W, R1, R2, R3, R4, R5, R6, R7 et R8 sont tels que définis dans la description. Les composés considérés sont des antagonistes de FSH efficaces et peuvent être utilisés par exemple pour le contrôle de la fertilité chez l'homme ou la femme, ou pour la prévention et/ou le traitement de l'ostéoporose.