3-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1268831-05-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 3-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• 英文别名: 3-pyrrolidin-1-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• CAS: 1268831-05-5
• 化学式: C₉H₁₂N₆
• 分子量: 204.234
• InChiKey: LFZNBIYBWWBFSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  83.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS INHIBITEURS DE RAF ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2011025947A1

  公开（公告）日：2011-03-03

  Compounds of Formula II are useful for inhibition of Raf kinases. Methods of using compounds of Formula II and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

  公式II的化合物对于抑制Raf激酶是有用的。公式II的化合物及其立体异构体、互变异构体、前药和药用盐的使用方法，用于体外、原位和体内对哺乳动物细胞中的这些疾病的诊断、预防或治疗，或相关病理条件。
• NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：NAGARATHNAM Dhanapalan

  公开号：US20120289496A1

  公开（公告）日：2012-11-15

  The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了PI3K蛋白激酶调节剂，其制备方法，含有它们的药物组合物，以及使用它们进行治疗、预防和/或改善激酶介导的疾病或紊乱的方法。
• RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Aliagas Ignacio

  公开号：US20120157453A1

  公开（公告）日：2012-06-21

  Compounds of Formula II are useful for inhibition of Raf kinases. Methods of using compounds of Formula II and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

  II式化合物可用于抑制Raf激酶。本文公开了使用II式化合物及其立体异构体、互变异构体、前药和药学上可接受的盐进行体外、体内和体内诊断、预防或治疗哺乳动物细胞中的这种疾病或相关病理条件的方法。
• Compounds as modulators of protein kinases
  申请人：Rhizen Pharmaceuticals SA

  公开号：US10220035B2

  公开（公告）日：2019-03-05

  The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了 PI3K 蛋白激酶调节剂、制备方法、含有这些调节剂的药物组合物以及用它们治疗、预防和/或改善激酶介导的疾病或紊乱的方法。
• Substituted chromenones as modulators of protein kinases
  申请人：Rhizen Pharmaceuticals SA

  公开号：US10322130B2

  公开（公告）日：2019-06-18

  The present invention provides PI3K protein kinase modulators of formula wherein R, Cy1, R1, R2, L1 and Cy2 are as defined herein. The present invention also relates to methods of preparing compounds of formula (I) to pharmaceutical compositions containing them and to methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供式 PI3K 蛋白激酶调节剂，其中 R、Cy1、R1、R2、L1 和 Cy2 如本文所定义。 本发明还涉及制备式（I）化合物的方法、含有式（I）化合物的药物组合物以及用式（I）化合物治疗、预防和/或改善激酶介导的疾病或紊乱的方法。