benzo[d]imidazo[2,1-b]thiazol-2-yl-(3,5-dimethyl-pyrazol-1-yl)-methanone | 909911-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: benzo[d]imidazo[2,1-b]thiazol-2-yl-(3,5-dimethyl-pyrazol-1-yl)-methanone
• 英文别名: (3,5-Dimethylpyrazol-1-yl)-imidazo[2,1-b][1,3]benzothiazol-2-ylmethanone
• CAS: 909911-83-7
• 化学式: C₁₅H₁₂N₄OS
• 分子量: 296.352
• InChiKey: JXMQFOMHXYFOQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  80.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Methods of screening for compounds which inhibit the activity of Cdc34 in a zinc-mediated manner and compounds obtained by this method
  申请人：Furet Pascal

  公开号：US20060211747A1

  公开（公告）日：2006-09-21

  The present invention relates to methods of searching/screening for compounds which inhibit the activity of the ubiquitin conjugating enzyme Cdc34 in a zinc-mediated manner, to compounds obtainable by such a method, to a method of treating mammalian subjects with such compounds, to pharmaceutical compositions containing such compounds, to the use of such compounds for the treatment of diseases which respond to an inhibition of the activity of Cdc34 such as proliferative diseases, especially tumor diseases, and to the use of such compounds for the preparation of such pharmaceutical compositions for the treatment of such diseases.

  本发明涉及一种通过锌介导方式抑制泛素结合酶Cdc34活性的化合物搜索/筛选方法，涉及通过这种方法获得的化合物，涉及使用这种化合物治疗哺乳动物受试者的方法，涉及含有这种化合物的药物组合物，涉及使用这种化合物治疗对Cdc34活性抑制有反应的疾病，如增殖性疾病，尤其是肿瘤疾病，以及使用这种化合物制备这种药物组合物以治疗这种疾病。