{5-[2-(3-benzyl-1-ethylureidomethyl)-4-trifluoromethylphenyl]-6-methoxypyridin-3-yl}acetic acid | 1219935-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: {5-[2-(3-benzyl-1-ethylureidomethyl)-4-trifluoromethylphenyl]-6-methoxypyridin-3-yl}acetic acid
• 英文别名: 2-[5-[2-[[Benzylcarbamoyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-methoxypyridin-3-yl]acetic acid
• CAS: 1219935-69-9
• 化学式: C₂₆H₂₆F₃N₃O₄
• 分子量: 501.505
• InChiKey: MQWROAXQEOBPOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
  申请人：HUTCHINSON John Howard

  公开号：US20100081673A1

  公开（公告）日：2010-04-01

  Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD 2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.

  本文描述了PGD2受体拮抗剂化合物。还描述了包括本文所述化合物的药物组合物，以及使用这些PGD2受体拮抗剂，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他PGD2依赖性或PGD2介导的疾病或病症的方法。
• US8049015B2
  申请人：——

  公开号：US8049015B2

  公开（公告）日：2011-11-01
• [EN] HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS<br/>[FR] ANTAGONISTES HÉTÉROARYLIQUES DES RÉCEPTEURS DE PROSTAGLANDINE D2
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2010037059A2

  公开（公告）日：2010-04-01

  Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.