6-Fluoro-17β-hydroxy-4-androsten-3-one | 171752-98-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 6-Fluoro-17β-hydroxy-4-androsten-3-one
• 英文别名: (8R,9S,10R,13S,14S,17S)-6-fluoro-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 171752-98-0
• 化学式: C₁₉H₂₇FO₂
• 分子量: 306.421
• InChiKey: GGQPTOITOZXLBE-DXNWCKCOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,17β-Bis<(trimethylsilyl)oxy>-3,5-androstadiene 在 N-fluoropyridinium pyridine heptafluorodiborate 作用下， 以 乙腈 为溶剂， 反应 18.0h， 以88%的产率得到6-Fluoro-17β-hydroxy-4-androsten-3-one
  参考文献：
  名称：

  N-fluoropyridinium pyridine heptafluorodiborate: a useful fluorinating agent

  摘要：

  DOI：

  10.1021/jo00020a051

文献信息

• composition and uses for influencing hair growth
  申请人：Schmidt Alfred

  公开号：US20110117218A1

  公开（公告）日：2011-05-19

  The invention describes a combination of at least one aromatase inhibitor selected from the group of chemical-synthetic aromatase inhibitors and aromatase inhibition exhibiting extracts of soya beans and rapeseed, respectively, and at least one plant extract that contains one or more active ingredient substance(s) extracted from the plant, which is(are) selected from the group of 5α reductase type I and/or type II inhibitors and androgen receptor blockers, said combination being contained for example in a composition and having special properties for influencing hair growth. Uses of this combination are also described.

  该发明描述了一种组合物，该组合物包括至少一种从化学合成芳香化酶抑制剂和大豆和油菜籽提取物中选择的芳香化酶抑制剂和至少一种植物提取物，该植物提取物含有从植物中提取的一个或多个活性成分，所述活性成分从5α还原酶I型和/或II型抑制剂和雄激素受体阻断剂中选择，该组合物例如包含在一种组合物中，并具有影响头发生长的特殊性质。还描述了该组合物的用途。
• Composition and uses for influencing hair growth
  申请人：S.W. Patentverwertungs Limited

  公开号：US11052059B2

  公开（公告）日：2021-07-06

  The invention describes a combination of at least one aromatase inhibitor selected from the group of chemical-synthetic aromatase inhibitors and aromatase inhibition exhibiting extracts of soya beans and rapeseed, respectively, and at least one plant extract that contains one or more active ingredient substance(s) extracted from the plant, which is(are) selected from the group of 5α reductase type I and/or type II inhibitors and androgen receptor blockers, said combination being contained for example in a composition and having special properties for influencing hair growth. Uses of this combination are also described.

  本发明描述了至少一种芳香化酶抑制剂（分别选自化学合成芳香化酶抑制剂和具有芳香化酶抑制作用的大豆和油菜籽萃取物）与至少一种植物萃取物的组合，该植物萃取物含有一种或多种从植物中提取的活性成分物质，这些活性成分物质选自 5α 还原酶 I 型和/或 II 型抑制剂以及雄激素受体阻断剂。此外，还介绍了这种组合物的用途。
• UMEMOTO TERUO; KAWADA KOSUKE; TOMITA KYOICHI, TETRAHEDRON LETT., 27,(1986) N 37, 4465-4468
  作者：UMEMOTO TERUO、 KAWADA KOSUKE、 TOMITA KYOICHI

  DOI：——

  日期：——
• ZUSAMMENSETZUNG UND VERWENDUNGEN ZUR BEEINFLUSSUNG DES HAARWACHSTUMS
  申请人：LUCOLAS-M.D. Ltd.

  公开号：EP2262471B1

  公开（公告）日：2015-10-28
• Substances and agents for positively influencing collagen
  申请人：Wieland Heinrich

  公开号：US20070148123A1

  公开（公告）日：2007-06-28

  The invention relates to the use of a substance and/or substances or a composition containing said substance and/or substances, whereby said substance and/or substances inhibit(s) the formation and/or the effect of estrogen to stabilize, increase and/or restore collagen. The appropriate substances are aromatase inhibitors and/or anti-estrogens. Optionally, 5-alpha-reductase inhibitors are also used.