1-Phenyl-1--2-methylamino-propan | 47131-36-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Phenyl-1--2-methylamino-propan
• 英文别名: N-methyl-1-naphthalen-1-yl-1-phenylpropan-2-amine
• CAS: 47131-36-2
• 化学式: C₂₀H₂₁N
• 分子量: 275.393
• InChiKey: GUPVRJQIYUEGGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  萘 、 erythro-(1S,2R)-1-chloro-1-phenyl-2-(methylamino)propane hydrochloride 在 三氯化铝 作用下， 生成 1-Phenyl-1--2-methylamino-propan
  参考文献：
  名称：

  Klosa,J., Journal fur praktische Chemie (Leipzig 1954), 1966, vol. 34, p. 335 - 340

  摘要：

  DOI：

文献信息

• Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
  申请人：Shionogi & Co., Ltd.

  公开号：US11345716B2

  公开（公告）日：2022-05-31

  Novel compounds having D3 receptor antagonistic activity are provided. A compound represented by formula (I): wherein ring A is a heterocycle, X1 is each independently CR4aR4b, X2 is each independently CR4cR4d, Y1 and Y2 are each independently a carbon atom or a nitrogen atom, L is —N(R6)—C(═O)— or the like, W is cyclyl or the like, R2 and R3 are each independently substituted or unsubstituted alkyl or the like, R1a, R1b, R4a to R4d, and R6 are each independently hydrogen atoms or the like, p is 1 or 2, q is an integer of 1 to 3, n is an integer of 1 to 4, s is an integer of 0 to 4, or a pharmaceutically acceptable salt thereof.

  提供了具有 D3 受体拮抗活性的新型化合物。 由式（I）代表的化合物： 其中 环 A 是杂环，X1 各自独立地为 CR4aR4b，X2 各自独立地为 CR4cR4d，Y1 和 Y2 各自独立地为碳原子或氮原子、 L是-N(R6)-C(═O)-或类似物，W是环烷基或类似物，R2和R3各自独立地是取代或未取代的烷基或类似物，R1a、R1b、R4a至R4d和R6各自独立地是氢原子或类似物、 p 是 1 或 2，q 是 1 至 3 的整数，n 是 1 至 4 的整数，s 是 0 至 4 的整数，或其药学上可接受的盐。
• NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 ANTAGONISTIC EFFECT
  申请人：Shionogi & Co., Ltd.

  公开号：US20210009607A1

  公开（公告）日：2021-01-14

  Novel compounds having D3 receptor antagonistic activity are provided. A compound represented by formula (I): wherein ring A is a heterocycle, X 1 is each independently CR 4a R 4b , X 2 is each independently CR 4c R 4d , Y 1 and Y 2 are each independently a carbon atom or a nitrogen atom, L is —N(R 6 )—C(═O)— or the like, W is cyclyl or the like, R 2 and R 3 are each independently substituted or unsubstituted alkyl or the like, R 1a , R 1b , R 4a to R 4d , and R 6 are each independently hydrogen atoms or the like, p is 1 or 2, q is an integer of 1 to 3, n is an integer of 1 to 4, s is an integer of 0 to 4, or a pharmaceutically acceptable salt thereof.