4-(4-甲氧基-苯基)-1-甲基-哌啶-4-醇 | 126120-73-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-(4-甲氧基-苯基)-1-甲基-哌啶-4-醇
• 英文名称: 4-(4-methoxy-phenyl)-1-methyl-piperidin-4-ol
• 英文别名: 4-hydroxy-4-(4-methoxyphenyl)-1-methylpiperidine；4-(4-Methoxyphenyl)-1-methylpiperidin-4-ol
• CAS: 126120-73-8
• 化学式: C₁₃H₁₉NO₂
• 分子量: 221.299
• InChiKey: GCSXGKPZMCKCKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-甲氧基-苯基)-1-甲基-哌啶-4-醇 在 甲醇 、 potassium hydrogensulfate 、 镍 作用下， 160.0 ℃ 、1.33 kPa 条件下， 生成 4-(1-methylpiperidin-4-yl)phenol
  参考文献：
  名称：

  PIPERIDINE DERIVATIVES. PART III. 4-ARYLPIPERIDINES¹

  摘要：

  DOI：

  10.1021/jo01170a022
• 作为产物：
  描述：

  N-甲基-4-哌啶酮 、 p-methoxyphenyllithium 以 四氢呋喃 为溶剂， 生成 4-(4-甲氧基-苯基)-1-甲基-哌啶-4-醇
  参考文献：
  名称：

  Assessment of Structural Requirements for the Monoamine Oxidase-B-Catalyzed Oxidation of 1,4-Disubstituted-1,2,3,6-tetrahydropyridine Derivatives Related to the Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

  摘要：

  The monoamine oxidase B (MAO-B) substrate properties and distance measurements along the N-1-C-4 axis of 38 1,4-disubstituted-1,2,3,6-tetrahydropyridine derivatives, including seven newly synthesized MPTP analogs, were used to define the maximum size that can be accommodated by the MAO-B active site. Only those compounds measuring less than 12 Angstrom displayed significant MAO-B substrate properties. The behavior of various 4-substituted-1-cyclopropyltetrahydropyl tetrahydropyridine analogs also is discussed in terms of this N-1-C-4 distance parameter in an effort to understand factors which contribute to their substrate vs inactivator properties. We conclude that this distance parameter will predict the majority of substrates vs nonsubstrates with this class of compound.

  DOI：

  10.1021/jm9603882

文献信息

• Selective NR2B Antagonists
  申请人：Bristol-Myers Squibb Company

  公开号：US20150191452A1

  公开（公告）日：2015-07-09

  The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

  该披露通常涉及到I式化合物，包括它们的盐，以及使用这些化合物的组合物和方法。这些化合物是NR2B受体的配体，可能对治疗中枢神经系统的各种疾病有用。
• [EN] 3-PHENYLSULPHONYL-QUINOLINE DERIVATIVES AS AGENTS FOR TREATING PATHOGENIC BLOOD VESSELS DISORDERS<br/>[FR] DÉRIVÉS DE 3-PHÉNYLSULFONYL-QUINOLÉINE EN TANT QU'AGENTS POUR LE TRAITEMENT DE TROUBLES DES VAISSEAUX SANGUINS PATHOGÈNES
  申请人：UNIV CALIFORNIA

  公开号：WO2021076886A1

  公开（公告）日：2021-04-22

  The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessles. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.

  该披露提供了化合物和组合物，包括药物组合物、包含这些化合物的试剂盒，以及使用（或给药）和制备这些化合物的方法。该披露进一步提供了用于调节PLXDC1（TEM7）和/或PLXDC2或杀灭病原性血管的方法中的化合物或其组合物。该披露还提供了用于治疗由PEDF受体或血管生成至少部分介导的疾病、紊乱或状况的方法中的化合物或其组合物。
• [EN] TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉ DE TRIAZOLOPYRIDINE, COMPOSITIONS ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：HOFFMANN LA ROCHE

  公开号：WO2015032286A1

  公开（公告）日：2015-03-12

  Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.

  本文描述了化合物的公式0、公式I和公式II，以及作为Janus激酶抑制剂使用的方法。
• 4-Pentafluorophenoxypiperidines
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US04914204A1

  公开（公告）日：1990-04-03

  4-Pentafluorophenoxypiperidines and methods for alleviating pain and treating depression, convulsions, and hypertension utilizing compounds or compositions thereof are disclosed.

  4-五氟苯氧哌啶和利用其化合物或组合物缓解疼痛、治疗抑郁症、癫痫和高血压的方法被披露。
• COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
  申请人：Alper Phillip B.

  公开号：US20090270409A1

  公开（公告）日：2009-10-29

  The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

  本发明提供了化合物、包含此类化合物的药物组合物以及使用此类化合物治疗或预防与GPR119活性相关的疾病或疾病的方法。