{3-[(1R,2S,3R)-2-((E)-4-Benzo[b]thiophen-3-yl-3-hydroxybut-1-enyl)-3-hydroxy-5-oxocyclopentylsulfanyl]propylsulfanyl}acetic acid | 502421-21-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: {3-[(1R,2S,3R)-2-((E)-4-Benzo[b]thiophen-3-yl-3-hydroxybut-1-enyl)-3-hydroxy-5-oxocyclopentylsulfanyl]propylsulfanyl}acetic acid
• 英文别名: 2-[3-[(1R,2S,3R)-2-[(E)-4-(1-benzothiophen-3-yl)-3-hydroxybut-1-enyl]-3-hydroxy-5-oxocyclopentyl]sulfanylpropylsulfanyl]acetic acid
• CAS: 502421-21-8
• 化学式: C₂₂H₂₆O₅S₃
• 分子量: 466.643
• InChiKey: FKNRIEMCAYUBLC-VWOJQHJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  174
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Combination therapy for glaucoma treatment
  申请人：Burk M. Robert

  公开号：US20050209194A1

  公开（公告）日：2005-09-22

  A method is disclosed herein comprising administering a compound and a second drug to an eye of a mammal for the treatment of glaucoma or the reduction of intraocular pressure, said compound represented by the general formula I; wherein A, B, D, X, Y, Z, R 1 , R 3 and R 4 are as defined in the specification.

  本方法包括向哺乳动物的眼睛内给予化合物和第二种药物，用于治疗青光眼或降低眼内压，所述化合物由一般式I表示；其中A、B、D、X、Y、Z、R1、R3和R4如规范中所定义。
• Treatment of inflammatory bowel disease
  申请人：Burk M. Robert

  公开号：US20050222094A1

  公开（公告）日：2005-10-06

  A method is disclosed herein comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound represented by the general formula I; wherein A, B, D, X, Y, Z, R 1 , R 3 and R 4 are as defined in the specification.

  本文公开了一种方法，包括向患有炎症性肠病的哺乳动物施用一种化合物以治疗该疾病，所述化合物由一般式I表示；其中A、B、D、X、Y、Z、R1、R3和R4如规范中定义。
• EP4 agonists as agents for lowering intraocular pressure
  申请人：Allergan, Inc.

  公开号：US20040102499A1

  公开（公告）日：2004-05-27

  The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound which is a EP 4 agonist.

  本发明提供了一种治疗眼高压或青光眼的方法，包括向患有眼高压或青光眼的动物施用治疗有效量的EP4激动剂化合物。
• 3, 7 OR 3 AND 7 THIA OR OXA PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE
  申请人：ALLERGAN, INC.

  公开号：EP1395263B1

  公开（公告）日：2009-12-30
• US6538018B1
  申请人：——

  公开号：US6538018B1

  公开（公告）日：2003-03-25