(4-Phenylmethoxyphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone | 1190486-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4-Phenylmethoxyphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
• CAS: 1190486-99-7
• 化学式: C₂₂H₂₂N₄O₂
• 分子量: 374.442
• InChiKey: CIWQTFNQROPJCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(2-嘧啶基)哌嗪 在 potassium carbonate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 生成 (4-Phenylmethoxyphenyl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone
  参考文献：
  名称：

  Novel inhibitors of the high-affinity l-proline transporter as potential therapeutic agents for the treatment of cognitive disorders

  摘要：

  The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the proline transporter (PROT), a high affinity Na(+)/Cl(-)-dependent transporter, indicated its potential as a novel therapeutic target for cognition improvement. Herein we report our investigation into a novel class of PROT inhibitors.

  DOI：

  10.1016/j.bmcl.2014.06.049

文献信息

• Novel inhibitors of the high-affinity l-proline transporter as potential therapeutic agents for the treatment of cognitive disorders
  作者：G. Greg Zipp、Joseph Barbosa、Michael A. Green、Kristen M. Terranova、Cynthia Fink、Xuan-Chuan Yu、Amr Nouraldeen、Alan Wilson、Katerina Savelieva、Thomas H. Lanthorn、S. David Kimball

  DOI：10.1016/j.bmcl.2014.06.049

  日期：2014.8

  The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the proline transporter (PROT), a high affinity Na(+)/Cl(-)-dependent transporter, indicated its potential as a novel therapeutic target for cognition improvement. Herein we report our investigation into a novel class of PROT inhibitors.