2-(2,2-Dimethyl-propyl)-4-methoxy-phenol | 101210-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(2,2-Dimethyl-propyl)-4-methoxy-phenol
• 英文别名: 2-(2,2-Dimethylpropyl)-4-methoxyphenol
• CAS: 101210-10-0
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: HLOQFNMDWVJFAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2,2-Dimethyl-propyl)-4-methoxy-phenol 在 lithium perchlorate 作用下， 以 甲醇 为溶剂， 以83%的产率得到2-(2,2-Dimethyl-propyl)-4,4-dimethoxy-cyclohexa-2,5-dienone
  参考文献：
  名称：

  一个方便的途径邻-akylated酚和醌单缩醛

  摘要：

  有效的，区域特异性的，收敛于邻烷基化的苯酚并因此成醌单缩醛的途径包括使相应的2-羟基羰基衍生物与烷基锂试剂反应，然后进行三乙基硅烷还原和电化学氧化。

  DOI：

  10.1039/c39850001291
• 作为产物：
  描述：

  2-(1-Hydroxy-2,2-dimethyl-propyl)-4-methoxy-phenol 在 三乙基硅烷 作用下， 以 三氟乙酸 为溶剂， 以94%的产率得到2-(2,2-Dimethyl-propyl)-4-methoxy-phenol
  参考文献：
  名称：

  一个方便的途径邻-akylated酚和醌单缩醛

  摘要：

  有效的，区域特异性的，收敛于邻烷基化的苯酚并因此成醌单缩醛的途径包括使相应的2-羟基羰基衍生物与烷基锂试剂反应，然后进行三乙基硅烷还原和电化学氧化。

  DOI：

  10.1039/c39850001291

文献信息

• Materials and methods for the detection of trace amounts of substances in biological and environmental samples
  申请人：Kabir Abuzar

  公开号：US10768157B2

  公开（公告）日：2020-09-08

  The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

  本发明提供了通过溶胶-凝胶工艺制造分子印迹聚合物（MIP）的化学成分和合成策略。在一个具体的实施方案中，本发明利用有机、无机或金属模板分析物来创建有机-无机或无机混合三维网络，该网络具有与模板分子或离子的形状、大小和功能取向互补的空穴。本发明还涉及将新型 MIPs 用作选择性固相萃取（SPE）吸附剂，用于生物和环境样品中痕量物质的预浓缩和净化。根据本发明的教导，可以合成对环境、制药、化学、临床、毒理学和国家安全有影响的其他分子印迹聚合物。
• CHEN, CHUNG-PIN;SWENTON, J. S., J. CHEM. SOC. CHEM. COMMUN., 1985, N 19, 1291-1292
  作者：CHEN, CHUNG-PIN、SWENTON, J. S.

  DOI：——

  日期：——
• MATERIALS AND METHODS FOR THE DETECTION OF TRACE AMOUNTS OF SUBSTANCES IN BIOLOGICAL AND ENVIRONMENTAL SAMPLES
  申请人：KABIR Abuzar

  公开号：US20180059082A1

  公开（公告）日：2018-03-01

  The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.