(2'S,2R,3S,4S)-{[3,4-dihydro-4-(furan-2-yl)-2-(4-nitrophenyl)-5-phenyl-2H-pyrrol-3-yl]-carbonyl}-2-oxo-4-phenyloxazolidine | 1197006-91-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (2'S,2R,3S,4S)-{[3,4-dihydro-4-(furan-2-yl)-2-(4-nitrophenyl)-5-phenyl-2H-pyrrol-3-yl]-carbonyl}-2-oxo-4-phenyloxazolidine
• CAS: 1197006-91-9
• 化学式: C₃₀H₂₃N₃O₆
• 分子量: 521.529
• InChiKey: GTMKRBHYZSUWEA-XAUNCYBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.85
• 重原子数：
  39.0
• 可旋转键数：
  6.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  115.25
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  (2'S,2R,3S,4S)-{[3,4-dihydro-4-(furan-2-yl)-2-(4-nitrophenyl)-5-phenyl-2H-pyrrol-3-yl]-carbonyl}-2-oxo-4-phenyloxazolidine 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 5.0h， 生成 ((2R,3S,4S)-4-(furan-2-yl)-3,4-dihydro-2-(4-nitrophenyl)-5-phenyl-2H-pyrrol-3-yl)methanol
  参考文献：
  名称：

  Nitrile Ylides: Diastereoselective Cycloadditions using Chiral Oxzolidinones Without Lewis Acid

  摘要：

  Lewis acid complexation is generally required for chiral-auxiliary-controlled stereoselectivity, and chiral Lewis acid catalysis is frequently optimal for introducing asymmetry. In this work, we show that nitrile ylide cycloadditions to electron-poor acceptors attached to chiral auxiliaries proceed in high yield and stereoselectivity In the absence of Lewis acids. In contrast, chiral Lewis acids are inferior in these cycloadditions.

  DOI：

  10.1021/ol9018584
• 作为产物：
  描述：

  (S)-3-((E)-3-(furan-2-yl)acryloyl)-4-phenyloxazolidin-2-one 、 N-(4-nitrobenzyl)benzimidoyl chloride 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以68%的产率得到(2'S,2R,3S,4S)-{[3,4-dihydro-4-(furan-2-yl)-2-(4-nitrophenyl)-5-phenyl-2H-pyrrol-3-yl]-carbonyl}-2-oxo-4-phenyloxazolidine
  参考文献：
  名称：

  Nitrile Ylides: Diastereoselective Cycloadditions using Chiral Oxzolidinones Without Lewis Acid

  摘要：

  Lewis acid complexation is generally required for chiral-auxiliary-controlled stereoselectivity, and chiral Lewis acid catalysis is frequently optimal for introducing asymmetry. In this work, we show that nitrile ylide cycloadditions to electron-poor acceptors attached to chiral auxiliaries proceed in high yield and stereoselectivity In the absence of Lewis acids. In contrast, chiral Lewis acids are inferior in these cycloadditions.

  DOI：

  10.1021/ol9018584