cis-[PtCl2(pyridine)(isoquinoline)] | 292036-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: cis-[PtCl2(pyridine)(isoquinoline)]
• 英文别名: dichloroplatinum;isoquinoline;pyridine
• CAS: 292036-17-0
• 化学式: C₁₄H₁₂Cl₂N₂Pt
• 分子量: 474.249
• InChiKey: ISZYXXZWAJYISI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  异喹啉 、 potassium trichloroplatinite(II) 以 乙醇 、 水 为溶剂， 以51%的产率得到cis-[PtCl2(pyridine)(isoquinoline)]
  参考文献：
  名称：

  Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

  摘要：

  A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme, It is noteworthy that the cis -[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10(-7) M. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0020-1693(00)00114-6