R-2HMP | 174656-15-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: R-2HMP
• 英文别名: (R)-N-(2-heptyl)methyl-propargylamine；(R)-N-(2-Heptyl) N-methylpropargylamine；R-2-heptyl-N-methylpropargylamine；(2R)-N-methyl-N-prop-2-ynylheptan-2-amine
• CAS: 174656-15-6
• 化学式: C₁₁H₂₁N
• 分子量: 167.294
• InChiKey: VNEMYKBWMWWZIU-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Compositions and Methods for Treatment of Cardiovascular Disorders and Diseases
  申请人：Technion Research & Development Foundation Ltd.

  公开号：EP2433626A1

  公开（公告）日：2012-03-28

  The present invention is directed to the use of S-(-)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical composition for prevention and/or treatment of a cardiovascular disease or disorder.

  本发明涉及 S-(-)-N-丙炔基-1-氨基茚满或其药学上可接受的盐用于制备预防和/或治疗心血管疾病或紊乱的药物组合物。
• Use of propargylamine as neuroprotective agent
  申请人：Youdim B.H. Moussa

  公开号：US20050191348A1

  公开（公告）日：2005-09-01

  Propargylamine and pharmaceutically acceptable salts thereof are useful for treating a disease, disorder or condition selected from the group consisting of: (i) a neurodegenerative disease, (ii) a dementia; (iii) an affective or mood disorder; (iv) drug use and dependence; (v) a memory loss disorder; (vi) an acute neurological traumatic disorder or neurotrauma; (vii) a demyelinating disease; (viii) a seizure disorder; (ix) a cerebrovascular disorder; (x) a behavior disorder; and (xi) a neurotoxic injury.

  丙炔胺及其药学上可接受的盐类可用于治疗选自以下组别的疾病、失调或病症(i) 神经退行性疾病；(ii) 痴呆症；(iii) 情感或情绪障碍；(iv) 药物使用和依赖；(v) 失忆症；(vi) 急性神经创伤性疾病或神经创伤；(vii) 脱髓鞘疾病；(viii) 癫痫发作；(ix) 脑血管疾病；(x) 行为障碍；以及 (xi) 神经毒性损伤。
• Compositions and methods for treating and preventing necrosis
  申请人：Nathan (Helena) Ilana

  公开号：US20050288368A1

  公开（公告）日：2005-12-29

  A method for treating and/or preventing cell necrosis and diseases associated therewith, comprising the inhibition of one or more elastase enzymes within said cells.

  一种治疗和/或预防细胞坏死及其相关疾病的方法，包括抑制所述细胞内的一种或多种弹性蛋白酶。
• IMMUNOSELECTIVE TARGETING AGENTS AND METHODS OF USE THEREOF
  申请人：Chalupa M. Leo

  公开号：US20060165705A1

  公开（公告）日：2006-07-27

  The present invention provides immunoselective targeting agents that bind to transporters that are transiently accessible on the surface of neuronal cells, and that deliver compounds selectively to such cells. The invention provides methods of selectively killing, as well as methods of selectively promoting survival of, a neuronal cell.

  本发明提供的免疫选择性靶向制剂能与神经元细胞表面可瞬时进入的转运体结合，并能选择性地向这些细胞递送化合物。本发明提供了选择性杀死神经元细胞的方法以及选择性促进神经元细胞存活的方法。
• ALIPHATIC PROPARGYLAMINES AS CELLULAR RESCUE AGENTS
  申请人：University of Saskatchewan Technologies Inc.

  公开号：EP0996612B1

  公开（公告）日：2003-04-09