2-[(5-Bromo-2-phenylphenyl)methyl]-1-benzothiophene | 761424-72-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-[(5-Bromo-2-phenylphenyl)methyl]-1-benzothiophene
• CAS: 761424-72-0
• 化学式: C₂₁H₁₅BrS
• 分子量: 379.32
• InChiKey: XRDVEFIAZWPZJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• C-GLYCOSIDE DERIVATIVES AND SALTS THEREOF
  申请人：Imamura Masakazu

  公开号：US20090069252A1

  公开（公告）日：2009-03-12

  The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na + -glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.

  本发明提供了C-糖苷衍生物及其盐，其中B环通过—X—与A环连接，A环直接与葡萄糖残基连接，可用作Na+-葡萄糖共转运体抑制剂，特别适用于治疗和/或预防糖尿病，如胰岛素依赖性糖尿病（1型糖尿病）和胰岛素非依赖性糖尿病（2型糖尿病），以及与糖尿病相关的疾病，如胰岛素抵抗性疾病和肥胖症。
• C-glycoside derivatives and salts thereof
  申请人：Imamura Masakazu

  公开号：US20070161787A1

  公开（公告）日：2007-07-12

  The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na + -glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.

  本发明提供了C-糖苷衍生物及其盐，其中B环通过—X—与A环连接，而A环直接与葡萄糖残基连接。该化合物可用作Na+-葡萄糖共转运体抑制剂，特别适用于治疗和/或预防糖尿病，如胰岛素依赖性糖尿病（1型糖尿病）和胰岛素非依赖性糖尿病（2型糖尿病），以及与糖尿病相关的疾病，如胰岛素抵抗性疾病和肥胖症。
• C-glycoside derivatives for the treatment of diabetes
  申请人：Astellas Pharma Inc.

  公开号：EP1980560A2

  公开（公告）日：2008-10-15

  The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via -X- and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.

  本发明提供了C-糖苷衍生物及其盐类，其中B环通过-X-与A环键合，A环直接与葡萄糖残基键合，可用作Na+-葡萄糖共转运体抑制剂，特别是用于治疗和/或预防糖尿病，如胰岛素依赖型糖尿病（1型糖尿病）和胰岛素非依赖型糖尿病（2型糖尿病），以及与糖尿病相关的疾病，如胰岛素抵抗性疾病和肥胖症。
• US7202350B2
  申请人：——

  公开号：US7202350B2

  公开（公告）日：2007-04-10
• US7772407B2
  申请人：——

  公开号：US7772407B2

  公开（公告）日：2010-08-10