2-(1-pirrolidinil)-7-metossicromone | 63961-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(1-pirrolidinil)-7-metossicromone
• 英文别名: 7-methoxy-2-pyrrolidin-1-yl-chromen-4-one；7-Methoxy-2-pyrrolidin-1-ylchromen-4-one
• CAS: 63961-66-0
• 化学式: C₁₄H₁₅NO₃
• 分子量: 245.278
• InChiKey: WJKZXLZQBLNBRZ-UHFFFAOYSA-N

物化性质

• 沸点：
  388.8±42.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(1-pirrolidinil)-7-metossicromone 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 11-methoxy-5-methyl-5,7-dihydro-chromeno[3',2':5,6]pyrano[3,2-c]quinoline-6,8-dione
  参考文献：
  名称：

  新的多环吡喃环系统

  摘要：

  1-氧代-3-二烷基氨基-1 H-萘并[ 2,1- b ]吡喃，4-羟基香豆素和甲醛的反应导致了1-氧代-2-（（2-氧代-4'-羟基-2' ħ -1'-苯并吡喃-3'-基）-melhyl J-3二烷基氨基- 1 H ^ -萘并[2,1- b ]吡喃。当这些化合物在冰醋酸中回流，发生环化和6通过裂解二烷基氨基基团产生了，8-二氧代-6 H，7 H，07-，5,15,16-三恶二苯并[ a，j ]-萘并苯，以类似的方式，从合适的产物开始，许多其他的三氧并萘或合成了氮杂二氧杂萘并衍生物。

  DOI：

  10.1002/jhet.5570150416

文献信息

• Inhibition of neutrophil O2− production by unsymmetrical methylene derivatives of benzopyrans: their use as potential antiinflammatory agents
  作者：Mauro Mazzei、Ramona Dondero、Enzo Sottofattori、Edon Melloni、Roberto Minafra

  DOI：10.1016/s0223-5234(01)01279-x

  日期：2001.12

  Some unsymmetrical derivatives of benzopyrans 9 were synthesized and tested to verify their PKC inhibitory activity. For this purpose, the Mannich bases of 7-hydroxycoumarins 6 were treated with 2-(dialkylamino)benzopyran-4-ones or 3-(dialkylamino)naphtho[2,1-b]pyran-1-ones 8 in the presence of acetic or propionic anhydride, yielding compounds 9. Human neutrophils stimulated with either PMA and f-MLF

  合成并测试了苯并吡喃9的一些不对称衍生物，以验证其对PKC的抑制活性。为此，在乙酸存在下，用2-（二烷基氨基）苯并吡喃-4-酮或3-（二烷基氨基）萘并[2,1-b]吡喃-1-酮8处理7-羟基香豆素6的曼尼希碱。用丙酸酐或丙酸酐产生化合物9。用PMA和f-MLF刺激的人类嗜中性粒细胞用作细胞模型。化合物9的效率建立在其减少活化的人类嗜中性粒细胞产生O（2）（-）的能力上。在色酮部分的7位带有乙酰氧基的化合物9d和9f似乎有效地抵消了中性粒细胞的活化。
• Synthesis of new 3,5-disubstituted isoxazoles with specific anti-group B rhinovirus activity in vitro
  作者：M Mazzei、A Balbi、E Sottofattori、R Garzoglio、A De Montis、S Corrias、P La Colla

  DOI：10.1016/0223-5234(93)90025-a

  日期：1993.1

  3,5-Disubstituted isoxazoles 4a-f were synthesized as potential anti-rhinovirus agents. These compounds were prepared in good yield by treatment of the corresponding 2-(dialkylamino)chromones 3a-f with hydroxylamine. Compounds 4 were demethylated to obtain dihydroxyderivatives 5, which were then transformed in acetyl-6 and alkylderivatives 7. The methylenbisderivatives 9 were obtained by reaction of bischromones 8 with hydroxylamine. Most compounds were subjected to antiviral screening. Compounds 4c, 7a, 7b and 7c were found to be specific inhibitors of group B rhinoviruses.
• Ermili,A. et al., Farmaco, Edizione Scientifica, 1977, vol. 32, p. 375 - 387
  作者：Ermili,A. et al.

  DOI：——

  日期：——
• Mazzei; Balbi; Ermili, Farmaco, Edizione Scientifica, 1985, vol. 40, # 12, p. 895 - 908
  作者：Mazzei、Balbi、Ermili、Sottofattori、Roma、Schiantarelli、Cadel

  DOI：——

  日期：——
• MAZZEI, M.;BALBI, A.;ERMILI, A.;SOTTOFATTORI, E.;SCHIANTARELLI, P.;CADEL,+, FARMACO. ED. SCI., 1985, 40, N 12, 895-908
  作者：MAZZEI, M.、BALBI, A.、ERMILI, A.、SOTTOFATTORI, E.、SCHIANTARELLI, P.、CADEL,+

  DOI：——

  日期：——