12-methoxynorfluorocurarine methyliodide | 1752-66-5

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 马钱子生物碱
• 英文名称: 12-methoxynorfluorocurarine methyliodide
• CAS: 1752-66-5
• 化学式: C₂₁H₂₅N₂O₂*I
• 分子量: 464.346
• InChiKey: HUKDFBHBTGDQCU-OXKCEDNWSA-N

反应信息

• 作为反应物：
  描述：

  12-methoxynorfluorocurarine methyliodide 在 水 、 sodium hydroxide 作用下， 以440 mg的产率得到12-methoxyfluorocurarine
  参考文献：
  名称：

  Structure of 12-methoxyfluorocurarine

  摘要：

  The crystal and molecular structures of quaternary salts and the quaternary base of 12-methoxynorfluorocurarine (vincanicine) that was isolated from the plant Vinca erecta were studied. The molecular structure, i.e., conformation, ring fusion, and absolute configuration (3S,7R,15S) of asymmetric centers, did not differ from that of norfluorocurarine. The carbonyl (C17=O) and N1H groups in the quaternary salts and base were mutually twisted and were involved in the crystal only in intermolecular H-bonds. The enol form in the zwitterionic alkaloid that existed in alkaline medium was observed in the crystal of 12-methoxynorfluorocurarine quaternary base.

  DOI：

  10.1007/s10600-013-0589-x