N-(5-bromopyridin-2-yl)-5-[2-(cycloheptylamino)-5-methylpyrimidin-4-yl]-N-(methoxymethyl)-1,3-thiazol-2-amine | 874477-04-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(5-bromopyridin-2-yl)-5-[2-(cycloheptylamino)-5-methylpyrimidin-4-yl]-N-(methoxymethyl)-1,3-thiazol-2-amine
• CAS: 874477-04-0
• 化学式: C₂₂H₂₇BrN₆OS
• 分子量: 503.466
• InChiKey: AIHBVGSKDIPHON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS<br/>[FR] COMPOSÉS DE PYRIDINE ET LEURS ANALOGUES AZA EN TANT QU'INHIBITEURS DE TYK2
  申请人：CELLZOME LTD

  公开号：WO2012062704A1

  公开（公告）日：2012-05-18

  The present invention relates to compounds of formula (I), wherein R1 to R3, X1, X2 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

  本发明涉及式(I)的化合物，其中R1至R3，X1，X2的含义如描述和权利要求中所述。所述化合物可用作TYK2抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导性疾病。该发明还涉及包括所述化合物的药物组合物，以及它们作为药物的用途。
• Selective Inhibitors Against Cdk4 and Cdk6 Having Aminothiazole Skeleton
  申请人：Iwasawa Yoshikazu

  公开号：US20080081811A1

  公开（公告）日：2008-04-03

  The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH 2 ; Y 1 , Y 2 , Y 3 , Y 4 and Y 5 , which may be identical or different, are each CH or N; however, at least one of Y 1 , Y 2 , Y 3 , Y 4 and Y 5 is N; Z 1 and Z 2 , which may be identical or different, are each CH or N; n is an integer from 1 to 3; R 1 is a C 3 -C 8 cycloalkyl group, a C 6 -C 10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R 2 and R 3 , which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C 3 -C 8 cycloalkyl group, a C 6 -C 10 aryl group, an aromatic heterocyclic ring, or the like; and R 4 is a hydrogen atom, a lower alkyl group, a C 3 -C 6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.

  本发明涉及一种由公式[I]表示的化合物：其中X为O、S、NH或CH2；Y1、Y2、Y3、Y4和Y5可以相同也可以不同，每个为CH或N；但是，至少有一个Y1、Y2、Y3、Y4和Y5为N；Z1和Z2可以相同也可以不同，每个为CH或N；n为1至3的整数；R1为C3-C8环烷基、C6-C10芳基、脂肪族杂环环或芳香族杂环环，或双环脂肪饱和碳氢基；R2和R3可以相同也可以不同，每个为氢原子、低碳基、低烯基、C3-C8环烷基、C6-C10芳基、芳香族杂环环等；R4为氢原子、低碳基、C3-C6环烷基或类似物的药学上可接受的盐或酯，以及一种针对Cdk4和/或Cdk6的选择性抑制剂或含有该化合物或其药学上可接受的盐或酯的抗癌剂。
• US7709475B2
  申请人：——

  公开号：US7709475B2

  公开（公告）日：2010-05-04