5-[(1R)-5-(4-chlorophthalazin-1-yl)oxy-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-2,4-dione | 1237522-60-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-[(1R)-5-(4-chlorophthalazin-1-yl)oxy-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-2,4-dione
• CAS: 1237522-60-9
• 化学式: C₂₀H₁₄ClN₃O₃S
• 分子量: 411.868
• InChiKey: YXBYKJFNIFFRFD-JBZHPUCOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PHTHALAZINE-CONTAINING ANTIDIABETIC COMPOUNDS
  申请人：Davis Jason L.

  公开号：US20120004234A1

  公开（公告）日：2012-01-05

  This invention provides for certain phthalazine-containing compounds of the formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof, wherein G is an optionally substituted N—N containing heteroaryl group and the variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.
• US8575166B2
  申请人：——

  公开号：US8575166B2

  公开（公告）日：2013-11-05