3-m-tolyl-2-(4-phenyl-2-phenylamino-thiazol-5-yl)-3H-quinazolin-4-one | 923552-74-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-m-tolyl-2-(4-phenyl-2-phenylamino-thiazol-5-yl)-3H-quinazolin-4-one
• 英文别名: 2-(2-anilino-4-phenyl-1,3-thiazol-5-yl)-3-(3-methylphenyl)-4(3H)-quinazolinone；2-(2-anilino-4-phenyl-1,3-thiazol-5-yl)-3-(3-methylphenyl)quinazolin-4-one
• CAS: 923552-74-3
• 化学式: C₃₀H₂₂N₄OS
• 分子量: 486.597
• InChiKey: ORNCWKMPHRYCKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  85.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS
  申请人：Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

  公开号：EP2007393A2

  公开（公告）日：2008-12-31
• Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers
  申请人：Giordano Anthony

  公开号：US20090306073A1

  公开（公告）日：2009-12-10

  Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.
• US8217037B2
  申请人：——

  公开号：US8217037B2

  公开（公告）日：2012-07-10
• US8829014B2
  申请人：——

  公开号：US8829014B2

  公开（公告）日：2014-09-09
• [EN] THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS<br/>[FR] THIAZOLE ET THIOPHENE ANALOGUES ET LEUR UTILISATION POUR TRAITER DES MALADIES AUTO-IMMUNES ET DES CANCERS
  申请人：UNIV LOUISIANA STATE

  公开号：WO2007118149A2

  公开（公告）日：2007-10-18

  [EN] Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.
  [FR] La présente invention concerne des composés de thiazole et de thiophène utilisables pour traiter des inflammations, des états immuno-inflammatoires, des maladies auto-immunes et des cancers. L'invention concerne également des procédés de synthèse de ces composés.