8-fluoro-5-{[2-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-2-trifluoromethylpropyl]amino}-2-methyl-quinazoline | 1070242-74-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 8-fluoro-5-{[2-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-2-trifluoromethylpropyl]amino}-2-methyl-quinazoline
• 英文别名: 1,1,1-Trifluoro-2-[[(8-fluoro-2-methylquinazolin-5-yl)amino]methyl]-3-(1,2,3,4-tetrahydronaphthalen-1-yl)propan-2-ol
• CAS: 1070242-74-8
• 化学式: C₂₃H₂₃F₄N₃O
• 分子量: 433.449
• InChiKey: OJSYOSHOCWGZAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  58
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Sbstituted chroman derivatives, processes for their preparation and their use as antiinflammatory agents
  申请人：Schmees Norbert

  公开号：US20070129358A1

  公开（公告）日：2007-06-07

  The invention relates to polysubstituted heterocyclic compounds of the general formula (I) processes for their preparation and their use as anti-inflammatory agents.

  该发明涉及通式（I）的多取代杂环化合物，以及它们的制备方法和作为抗炎药物的用途。
• Branched diene-modified crystalline polypropylene terpolymers
  申请人：——

  公开号：US20040110909A1

  公开（公告）日：2004-06-10

  Certain specific embodiments of the invention will now be discussed. For example, a process of preparing a polymer composition that includes a branched crystalline diene-modified polypropylene random terpolymer is described, which process includes: contacting a metallocene catalyst compound with a polymerization medium that includes at least a propylene monomer, a first diene monomer, and a second diene monomer; and conducting polymerization of the monomers in the presence of the metallocene catalyst compound for a time sufficient to provide a branched crystalline diene-modified polypropylene random terpolymer that includes monomeric units derived from each of the monomers, and having from 0.0 wt % to 2.0 wt % ethylene and a heat of fusion of 30 J/g or more

  现在将讨论本发明的某些具体实施例。例如，本发明描述了一种制备聚合物组合物的工艺，该聚合物组合物包括支链结晶二烯改性聚丙烯无规三元共聚物，该工艺包括将茂金属催化剂化合物与聚合介质接触，该聚合介质至少包括丙烯单体、第一二烯单体和第二二烯单体；在茂金属催化剂化合物存在下，使单体聚合足够长的时间，以提供支链结晶二烯改性聚丙烯无规三元共聚物，该聚丙烯无规三元共聚物包括衍生自每种单体的单体单元，并具有 0.0 wt % 至 2.0 wt % 的乙烯，熔融热为 30 J/g 或更高
• Multiple catalyst system for olefin polymerization and polymers produced therefrom
  申请人：Jiang Peijun

  公开号：US20070293640A1

  公开（公告）日：2007-12-20

  This invention relates to a polymer comprising one or more C3 to C40 olefins, optionally one or more diolefins, and less than 15 mole % of ethylene, where the polymer has: a) a Dot T-Peel of 1 Newton or more; and b) a branching index (g′) of 0.95 or less measured at the Mz of the polymer; c) an Mw of 100,000 or less. This invention also relates a polymer comprising one or more C3 to C40 olefins where the polymer has: a) a Dot T-Peel of 1 Newton or more on Kraft paper; b) a branching index (g′) of 0.95 or less measured at the Mz of the polymer; c) a Mw of 10,000 to 100,000; and d) a heat of fusion of 1 to 70 J/g. This invention also relates a polymer comprising one or more C3 to C40 olefins where the polymer has: a) a Dot T-Peel of 1 Newton or more on Kraft paper; b) a branching index (g′) of 0.98 or less measured at the Mz of the polymer; c) a Mw of 10,000 to 60,000; d) a heat of fusion of 1 to 50 J/g. This invention also relates to a homopolypropylene or a copolymer of propylene and up to 5 mole % ethylene having: a) an isotactic run length of 1 to 30 (isotactic run length “IRL” is defined to be the percent of mmmm pentad divided by 0.5× percent of mmmr pentad) as determined by Carbon 13 NMR, preferably 3 to 25, more preferably 4 to 20, b) a percent of r dyad of greater than 20%, preferably from 20 to 70% as determined by Carbon 13 NMR, and c) a heat of fusion of 70 J/g or less, preferably 60 J/g or less, more preferably between 1 and 55 J/g, more preferably between 4 and 50 J/g. This invention further relates to a process to produce an olefin polymer comprising: 1) selecting a first catalyst component capable of producing a polymer having an Mw of 100,000 or less and a crystallinity of 5% or less at selected polymerization conditions; 2) selecting a second catalyst component capable of producing polymer having an Mw of 100,000 or less and a crystallinity of 20% or more at the selected polymerization conditions; 3) contacting the catalyst components in the presence of one or more activators with one or more C3 to C40 olefins, at the selected polymerization conditions in a reaction zone; 4) obtaining the polymer. This invention further relates to a continuous process to produce a branched olefin polymer comprising: 1) selecting a first catalyst component capable of producing a polymer having an Mw of 100,000 or less and a crystallinity of 5% or less under selected polymerization conditions; 2) selecting a second catalyst component capable of producing polymer having an Mw of 100,000 or less and a crystallinity of 20% or more at the selected polymerization conditions; 3) contacting the catalyst components in the presence of one or more activators with one or more C3 to C40 olefins, and, optionally one or more diolefins; 4) at a temperature of greater than 100° C.; 5) at a residence time of 120 minutes or less; 6) wherein the ratio of the first catalyst to the second catalyst is from 1:1 to 50:1; 7) wherein the activity of the catalyst components is at least 100 kilograms of polymer per gram of the catalyst components; and wherein at least 20% of the olefins are converted to polymer.
• US7223828B2
  申请人：——

  公开号：US7223828B2

  公开（公告）日：2007-05-29
• US7265193B2
  申请人：——

  公开号：US7265193B2

  公开（公告）日：2007-09-04