4-(5-苯基-1,3,4-噁二唑-2-基)哌啶-1-甲酸叔丁酯 | 280110-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-(5-苯基-1,3,4-噁二唑-2-基)哌啶-1-甲酸叔丁酯
• 英文名称: 4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
• CAS: 280110-70-5
• 化学式: C₁₈H₂₃N₃O₃
• 分子量: 329.399
• InChiKey: KRFMLZFLQRQWIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  68.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(5-苯基-1,3,4-噁二唑-2-基)哌啶-1-甲酸叔丁酯 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 4-(5-苯基-1,3,4-噁二唑-2-基)哌啶
  参考文献：
  名称：

  Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains

  摘要：

  一系列含有哌啶-噁二唑侧链的新型三唑类抗真菌药物被设计并合成。化合物11b 对白念珠菌表现出高活性，最小抑菌浓度（MIC）值为0.016 μg/mL。

  DOI：

  10.1039/c4md00505h
• 作为产物：
  描述：

  N-Boc-4-哌啶甲酸甲酯 在 一水合肼 、 三乙胺 、 对甲苯磺酰氯 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 12.0h， 生成 4-(5-苯基-1,3,4-噁二唑-2-基)哌啶-1-甲酸叔丁酯
  参考文献：
  名称：

  Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains

  摘要：

  一系列含有哌啶-噁二唑侧链的新型三唑类抗真菌药物被设计并合成。化合物11b 对白念珠菌表现出高活性，最小抑菌浓度（MIC）值为0.016 μg/mL。

  DOI：

  10.1039/c4md00505h

文献信息

• [EN] NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS 2-PIPERIDIN-1-YL-ACETAMIDE UTILISABLES EN TANT QU'INHIBITEURS DE TANKYRASE
  申请人：NOVARTIS AG

  公开号：WO2013012723A1

  公开（公告）日：2013-01-24

  The present invention provides for compounds of formula (I), wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

  本发明提供了式(I)的化合物，其中R1-R5和L在此处定义。本发明还提供了包含式(I)化合物的药物组合物和组合物，以及将这些化合物用作坦基酶抑制剂以及用于治疗Wnt信号和坦基酶1和2信号相关疾病的用途，包括但不限于癌症。
• AMIDE COMPOUNDS
  申请人：Kitamura Shuji

  公开号：US20120065196A1

  公开（公告）日：2012-03-15

  The present invention provides compounds represented by the formula (Ie): and the formula (If): wherein each symbol is as defined in the specification. According to the present invention, these compounds have a DGAT inhibitory activity and are useful for the prophylaxis, treatment or improvement of diseases or pathologies caused by high expression or high activation of DGAT.

  本发明提供由式(Ie)和式(If)所表示的化合物，其中每个符号如规范中所定义。根据本发明，这些化合物具有DGAT抑制活性，并可用于预防、治疗或改善由DGAT高表达或高活化引起的疾病或病理学。
• Azole compound
  申请人：Astellas Pharma Inc.

  公开号：US08207199B2

  公开（公告）日：2012-06-26

  A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridine-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.

  提供了一种化合物，该化合物可作为制备用于治疗神经病性疼痛的药物组合物的活性成分。本发明人对具有FAAH抑制活性的化合物进行了广泛的研究，并发现一种咪唑化合物，其取代有N-(吡啶-3-基)氧羰基哌啶-4-基团和苯基，或其药学上可接受的盐具有出色的FAAH抑制活性，从而完成了本发明。本发明的化合物已被证实在神经病性疼痛的大鼠模型中具有出色的FAAH抑制活性和抗痛觉过敏作用，因此可用作预防和/或治疗神经病性疼痛的药剂。
• NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
  申请人：Cheung Atwood Kim

  公开号：US20150025070A1

  公开（公告）日：2015-01-22

  The present invention provides for compounds of formula (I): wherein R 1 -R 5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

  本发明提供了公式（I）的化合物：其中R1-R5和L在此定义。本发明还提供了含有公式（I）化合物的药物组合物和组合物，以及将这些化合物用作坦克酶抑制剂和治疗与Wnt信号和坦克酶1和2信号相关的疾病的用途，包括但不限于癌症。
• 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
  申请人：Cheung Atwood Kim

  公开号：US09181266B2

  公开（公告）日：2015-11-10

  The present invention provides for compounds of formula (I): wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

  本发明提供了式(I)的化合物，其中R1-R5和L如本文所定义。本发明还提供了包含式(I)化合物的药物组合物和制剂，以及将这些化合物用作坦克酶抑制剂和治疗Wnt信号和与坦克酶1和2信号相关的疾病的用途，包括但不限于癌症。