Cholestane-3,7,12,24,25-pentol | 58580-61-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Cholestane-3,7,12,24,25-pentol
• 英文别名: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(2R,5S)-5,6-dihydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol
• CAS: 58580-61-3
• 化学式: C₂₇H₄₈O₅
• 分子量: 452.7
• InChiKey: NHPWQASMMFUHIZ-YBMOUMCLSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  101
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hex-4-enyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol 生成 Cholestane-3,7,12,24,25-pentol
  参考文献：
  名称：

  BATTA, ASHOK K.;AGGARWAL, SURESHT K.;SALEN, GERALS, 197TH ACS NAT. MEET., DALLAS, TEX., APR. 9-14, 1989, WASHINGTON (D. C.),(+

  摘要：

  DOI：

文献信息

• METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER
  申请人：Haggerty Timothy J.

  公开号：US20140335050A1

  公开（公告）日：2014-11-13

  The invention features methods, compositions, and kits for the administration of an HSP90 inhibitor, OBAA, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a TAA, an antigen-binding scaffold (e.g., an antibody, a soluble T cell receptor, or a chimeric receptor) specific for a TAA, a cell (e.g., a white blood cell that targets a cancer cell), and/or an IFN-β receptor agonist or an IFN-γ receptor agonist, for the treatment of cancer.
• BATTA, ASHOK K.;AGGARWAL, SURESHT K.;SALEN, GERALS, 197TH ACS NAT. MEET., DALLAS, TEX., APR. 9-14, 1989, WASHINGTON (D. C.),(+
  作者：BATTA, ASHOK K.、AGGARWAL, SURESHT K.、SALEN, GERALS

  DOI：——

  日期：——