4-ethyl-3,4-dihydronaphthalen-2-(1H)-one | 1190848-08-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-ethyl-3,4-dihydronaphthalen-2-(1H)-one
• 英文别名: 4-ethyl-3,4-dihydro-1H-naphthalen-2-one
• CAS: 1190848-08-8
• 化学式: C₁₂H₁₄O
• 分子量: 174.243
• InChiKey: HNCKPTYBALNYOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 四氟硼酸-二乙醚络合物 作用下， 反应 0.5h， 以82%的产率得到4-ethyl-3,4-dihydronaphthalen-2-(1H)-one
  参考文献：
  名称：

  通过炔醇或烯炔的阳离子催化环化反应合成环己酮

  摘要：

  已经开发了通过阳离子环化从炔醇或烯炔衍生物合成环己酮的新方法。的关键点，以获得六元环衍生物是使用开始含有末端炔的材料，使用四氟硼酸作为阳离子环化的启动子，和1,1,1,3,3-适当的选择， 3-三氟丙烷-2-醇（HFIP）作为溶剂。该策略可以扩展到几种萜烯衍生的多烯的仿生阳离子环化反应。

  DOI：

  10.1021/acs.orglett.8b00437

文献信息

• A concise method for the synthesis of 2-tetralone by titanium tetrachloride-promoted cyclization of 4-aryl-2-hydroxybutanal diethyl acetal
  作者：Yung-Son Hon、Rammohan Devulapally

  DOI：10.1016/j.tetlet.2009.07.129

  日期：2009.10

  4-Aryl-2-hydroxybutanal diethyl acetal, prepared from the reaction of benzyl Grignard reagent and glycidaldehyde diethyl acetal, was treated with titanium tetrachloride to give 2-tetralone in good yield. This highly efficient transformation involves tandem oxonium formation, intramolecular Friedel–Crafts alkylation, deethoxylation, and tautomerization in the same flask.

  由苄基格氏试剂和缩水甘油醛二乙基缩醛反应制得的4-芳基-2-羟基丁醛二乙基缩醛用四氯化钛处理，以良好的收率得到2-四氢萘酮。这种高效的转化过程包括在同一烧瓶中形成串联的氧鎓，分子内的Friedel-Crafts烷基化反应，脱乙氧基化反应和互变异构反应。
• Lewis Acid Promoted Dearomatization of Naphthols
  作者：Kirill Kulish、Cosimo Boldrini、Marta Castiñeira Reis、Juana M. Pérez、Syuzanna R. Harutyunyan

  DOI：10.1002/chem.202003392

  日期：2020.12.4

  Two‐step dearomative functionalization of naphthols promoted by Lewis acids and copper(I) catalysis was developed. Initially, Lewis acid complexation inverted the electronic properties of the ring and established an equilibrium with the dearomatized counterpart. Subsequent trapping of the dearomatized intermediate with organometallics as well as organophosphines was demonstrated and provided the corresponding

  开发了路易斯酸和铜（I）催化促进萘的两步脱芳香化功能。最初，路易斯酸络合使环的电子性质反转，并与脱芳构化的对应物建立平衡。证实了脱芳香化的中间体随后被有机金属以及有机膦所捕获，并提供了相应的脱芳香化产品。
• Alkyne Compounds for Treatment of Complement Mediated Disorders
  申请人：ACHILLION PHARMACEUTICALS, INC.

  公开号：US20150239868A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R 12 or R 13 on the A group is an alkyne (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  本文提供了包含化合物I式，或其药学上可接受的盐或组成物的补体因子D抑制剂的制备方法和使用方法，其中A组上的R12或R13是炔基（R32）。所述的抑制剂靶向因子D，并在替代补体途径的早期和关键点抑制或调节补体级联反应，并减少因子D调节经典和凝集素补体途径的能力。本文所述的因子D抑制剂能够减少过度激活补体，这与某些自身免疫性、炎症性和神经退行性疾病以及缺血再灌注损伤和癌症有关。
• COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20160361329A1

  公开（公告）日：2016-12-15

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement.
• US9828396B2
  申请人：——

  公开号：US9828396B2

  公开（公告）日：2017-11-28