diethyl 1-ethylhydrazine-1,2-dicarboxylate | 98998-78-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: diethyl 1-ethylhydrazine-1,2-dicarboxylate
• 英文别名: Ethylhydrazin-dicarbonsaeure-(1,2)-diethylester；ethyl N-(ethoxycarbonylamino)-N-ethylcarbamate
• CAS: 98998-78-8
• 化学式: C₈H₁₆N₂O₄
• 分子量: 204.226
• InChiKey: FUYACVYGDUGUGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  diethyl N-ethyl-N'-(diethylphosphoryl)hydrazodicarboxylate 在 氢碘酸 作用下， 生成 diethyl 1-ethylhydrazine-1,2-dicarboxylate
  参考文献：
  名称：

  Ginsburg,V.A. et al., Journal of general chemistry of the USSR, 1960, vol. 30, p. 2834 - 2841

  摘要：

  DOI：

文献信息

• Iron-Catalyzed Photoredox Functionalization of Methane and Heavier Gaseous Alkanes: Scope, Kinetics, and Computational Studies
  作者：Qingqing Zhang、Shuyang Liu、Jinglan Lei、Yongqiang Zhang、Changgong Meng、Chunying Duan、Yunhe Jin

  DOI：10.1021/acs.orglett.2c00224

  日期：2022.3.18

  Herein, we report the development of the photocatalytic C–H functionalization of methane, ethane, and heavier gaseous alkanes with good yields and selectivity, broad scope (57 examples), mild conditions, and low cost. Kinetics and density functional theory calculations were investigated for the key photoinduced ligand-to-metal charge transfer and hydrogen atom transfer processes to reveal the detailed

  在此，我们报告了甲烷、乙烷和较重的气态烷烃的光催化 C-H 官能化的发展，具有良好的收率和选择性、广泛的范围（57 个示例）、温和的条件和低成本。研究了关键的光诱导配体-金属电荷转移和氢原子转移过程的动力学和密度泛函理论计算，以揭示铁光催化的详细机制。这项工作可能为原料升级和催化剂设计带来新的思路。
• APPLICATION OF 2,5 -DIHYDROXYMETHYL -3,6 - DIMETHYL PYRAZINE AND ITS DERIVATES IN PHARMACY
  申请人：Li Wei

  公开号：US20110195972A1

  公开（公告）日：2011-08-11

  An application of 2,5-dihydroxymethyl-3,6-dimethyl pyrazine and its derivatives in the preparation of drugs for the treatment of, prevention of, and/or protection from heart failure wherein the structural formula of the compound is as follows:

  2,5-二羟甲基-3,6-二甲基吡嗪及其衍生物在制备用于治疗、预防和/或保护心力衰竭的药物中的应用，其中该化合物的结构式如下：
• 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Adams Jerry Leroy

  公开号：US20080287466A1

  公开（公告）日：2008-11-20

  Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

  本文描述了作为TIE-2和/或VEGFR-2抑制剂有用的呋喃和噻唑嘧啶衍生物。所述发明还包括制备这种呋喃和噻唑嘧啶衍生物的方法以及使用它们治疗增生性疾病的方法。
• Diethylzinc: A Chain-Transfer Agent in Intermolecular Radical Additions. A Parallel with Triethylborane
  作者：Michèle P. Bertrand、Laurence Feray、Robert Nouguier、P. Perfetti

  DOI：10.1021/jo9912404

  日期：1999.12.1

  In the presence of oxygen, diethylzinc can be used to promote radical additions to C=N bond containing radical accepters and to enones. In these reactions, it plays at the same time the role of the initiator and the role of the chain-transfer reagent. A parallel with triethylborane-mediated reactions is established. The methodology is restricted to secondary and tertiaryalkyl radicals generated from the corresponding alkyl iodides. It could not be extended either to C=C bond containing radical accepters such as methyl methacrylate and nitrocyclohexene or to diethylazodicarboxylate.
• US7427623B2
  申请人：——

  公开号：US7427623B2

  公开（公告）日：2008-09-23