5-(aminomethyl)-6-quinoxalinol hydochloride | 84174-57-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-(aminomethyl)-6-quinoxalinol hydochloride
• 英文别名: 5-(Aminomethyl)quinoxalin-6-ol;hydrochloride；5-(aminomethyl)quinoxalin-6-ol;hydrochloride
• CAS: 84174-57-2
• 化学式: C₉H₉N₃O*ClH
• 分子量: 211.651
• InChiKey: RAMWMAOUUDEMOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.22
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  72
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-羟基喹喔啉 在 盐酸 、 三氟化硼乙醚 作用下， 反应 7.0h， 生成 5-(aminomethyl)-6-quinoxalinol hydochloride
  参考文献：
  名称：

  2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogs

  摘要：

  A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydrochloride (2) and 7-(aminomethyl)-6-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalene hydrochloride (6) displayed a high order of activity.

  DOI：

  10.1021/jm00358a023

文献信息

• DEANA, A. A.;STOKKER, G. E.;SCHULTZ, E. M.;SMITH, R. L.;CRAGOE, E. J. ,, +, J. MED. CHEM., 1983, 26, N 4, 580-585
  作者：DEANA, A. A.、STOKKER, G. E.、SCHULTZ, E. M.、SMITH, R. L.、CRAGOE, E. J. ,, +

  DOI：——

  日期：——
• 2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogs
  作者：A. A. Deana、G. E. Stokker、E. M. Schultz、R. L. Smith、E. J. Cragoe、H. F. Russo、L. S. Watson

  DOI：10.1021/jm00358a023

  日期：1983.4

  A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydrochloride (2) and 7-(aminomethyl)-6-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalene hydrochloride (6) displayed a high order of activity.