(1-Methylcyclooctyl)methanamine | 1513677-88-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1-Methylcyclooctyl)methanamine
• CAS: 1513677-88-7
• 化学式: C₁₀H₂₁N
• 分子量: 155.28
• InChiKey: MIBUYJFUZBQMCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• 1,4-DI-SUBSTITUTED IMIDAZOLE DERIVATIVE
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：EP3312170A1

  公开（公告）日：2018-04-25

  The present invention provides a 1,4-disubstituted imidazole derivative of formula (1') wherein ring Q1 is optionally-substituted C6-10 aryl group, etc.; R1 and R2 are independently hydrogen atom, etc.; W1 is optionally-substituted C1-4 alkylene group; W2 is -NR3aC(O)- wherein R3a is hydrogen atom or C1-6 alkyl group, etc.; ring Q2 is 5- to 10-membered heteroaryl group, etc.; W3 is optionally-substituted C1-4 alkylene group, etc.; n is 1, 2, 3, 4, or 5; R4 is independently halogen atom, optionally-substituted C1-6 alkyl group, etc.; R5 is hydroxy group, etc.; and a pharmacologically acceptable salt thereof, which have a potent inhibitory effect on the sphere-forming capacity of cancer cells and are useful as an orally-available anti-tumor agent.

  本发明提供了式(1')的1,4-二取代咪唑衍生物，其中环Q1为任选取代的C6-10芳基等；R1和R2独立地为氢原子等；W1为任选取代的C1-4亚烷基；W2为-NR3aC(O)-，其中R3a为氢原子或C1-6烷基等；环Q2为5至10元杂芳基等；W3为任选取代的C1-4亚烷基等；n为1、2、3、4或5；R4独立地为卤素原子、任选取代的C1-6烷基等。W3 是任选取代的 C1-4 亚烷基等；n 是 1、2、3、4 或 5；R4 独立地是卤素原子、任选取代的 C1-6 烷基等；R5 是羟基等；及其药理学上可接受的盐，它们对癌细胞的球形成能力具有强效抑制作用，可作为口服抗肿瘤药使用。
• Wound closure method apparatus and system
  申请人：Thompson G. Alan

  公开号：US20090131979A1

  公开（公告）日：2009-05-21

  Disclosed is a wound closure device, such as a suture, including a substantially flexible tensile member, the tensile member having an external surface, the external surface including a biocidal material such as a coating of substantially pure silver. A method of applying the suture includes piercing a patient's skin adjacent to a wound using, for example, a needle and drawing a substantially flexible tensile member through a resulting aperture in the skin. By virtue of the biocidal material, pathogens and other bioactive materials drawn through the aperture are rendered less active and/or incapable of causing infection.
• SIMPLE SUGAR CONCENTRATION SENSOR AND METHOD WITH NARROWED OPTICAL PATH AND INTERROGATOR BEAM
  申请人：K Sciences GP, LLC

  公开号：US20200214606A1

  公开（公告）日：2020-07-09

  A glucose sensor comprising one or more optical energy source is disclosed. In various embodiments one or more beam splitter/combiner is implemented to receive optical energy from the one or more optical energy source. One or more beam splitter/combiner provides provide optical energy to detector(s) to determine glucose in a body tissue.