6-Hydroxy-3,4-dihydro-isochinolin | 16661-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 6-Hydroxy-3,4-dihydro-isochinolin
• 英文别名: 3,4-dihydro-isoquinolin-6-ol；6-hydroxy-3,4-dihydroisoquinoline；3,4-dihydroisoquinolin-6-ol
• CAS: 16661-40-8
• 化学式: C₉H₉NO
• 分子量: 147.177
• InChiKey: LXCGNQDVKGRQMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo[2,3-e]quinolizine derivatives
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0524004A1

  公开（公告）日：1993-01-20

  Compounds of the formula wherein:    X and Y are independently hydrogen; hydroxy; lower alkyl of 1-6 carbon atoms; lower alkoxy of 1-6 carbon atoms; or halo; or X and Y when adjacent and taken together are methylenedioxy or ethylene-1,2-dioxy;    R is lower alkyl of 1-6 carbon atoms; cycloalkyl of 3-8 carbon atoms; phenyl or phenyl lower alkyl in which any phenyl group may be optionally substituted by one or two substituents chosen from the group consisting of halo, lower alkyl of 1-4 carbon atoms and lower alkoxy of 1-4 carbon atoms; or -ANHSO₂R¹; wherein A is lower alkylene of 1-6 carbon atoms; and R¹ is lower alkyl of 1-6 carbon atoms or -NR²R³; wherein       R² and R³ are independently hydrogen or lower alkyl of 1-6 carbon atoms, or R² and R³ taken together are cycloalkyl of 3-8 carbon atoms; and    n is 1 or 2;    and the pharmaceutically acceptable salts thereof, are useful as α₂-adrenoceptor antagonists, in particular as peripherally selective α₂ -adrenoceptor antagonists.

  该式化合物中：X和Y分别是氢；羟基；1-6个碳原子的低烷基；1-6个碳原子的低烷氧基；或卤素；或当相邻时一起取为亚甲二氧基或乙烯-1,2-二氧基；R是1-6个碳原子的低烷基；3-8个碳原子的环烷基；苯基或苯基低烷基，其中任何苯基可以选择性地被来自卤素、1-4个碳原子的低烷基和1-4个碳原子的低烷氧基的一种或两种取代基取代；或-ANHSO₂R¹；其中A是1-6个碳原子的低烷基；R¹是1-6个碳原子的低烷基或-NR²R³；其中R²和R³分别是氢或1-6个碳原子的低烷基，或R²和R³一起取为3-8个碳原子的环烷基；n为1或2；以及其药用盐，可用作α₂-肾上腺素受体拮抗剂，特别是外周选择性α₂-肾上腺素受体拮抗剂。
• Process for the preparation of (8aS,12aS,13aS)-decahydroisoquino[2,1-g][1,6]-naphthyridin-8-one derivatives
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0505183A2

  公开（公告）日：1992-09-23

  The invention provides a process for preparing single enantiomers of compounds represented by the formula : and chiral acid addition salts thereof ; wherein : X and Y are independently hydrogen ; lower alkyl ; lower alkoxy; or halo; or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy; which includes reduction of a compound represented by the formula : to give a mixture of stereoisomers represented by the formula : wherein each wavy line independently represents a bond in either the α or β position ; followed by dissolving the mixture of stereoisomers and a chiral resolving acid in a suitable solvent and allowing the solution to crystallize, giving a salt of the desired enantiomer.

  本发明提供了一种制备由式......表示的化合物的单一对映体的工艺： 及其手性酸加成盐的工艺； 其中： X和Y独立地为氢；低级烷基；低级烷氧基；或卤素；或X和Y合起来为亚甲基二氧基或乙烯-1,2-二氧基； 其中包括还原由式： 式所代表的化合物进行还原，得到由式所代表的立体异构体混合物： 其中每条波浪线独立地代表 α 或 β 位置上的键； 然后将立体异构体混合物和手性溶解酸溶解在合适的溶剂中，使溶液结晶，得到所需对映异构体的盐。
• US5229387A
  申请人：——

  公开号：US5229387A

  公开（公告）日：1993-07-20
• US5231181A
  申请人：——

  公开号：US5231181A

  公开（公告）日：1993-07-27