8,9-dimethoxy-4,6,11,11a-tetrahydro-1H-benzoquinolizin-2(3H)-one | 16675-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 8,9-dimethoxy-4,6,11,11a-tetrahydro-1H-benzoquinolizin-2(3H)-one
• 英文别名: 8,9-dimethoxy-3,4,11,11a-tetrahydro-1H-benzoquinolizin-2(6H)-on；8,9-dimethoxy-1,3,4,6,11,11a-hexahydro-pyrido[1,2-b]isoquinolin-2-one；8.9-Dimethoxy-3,4,11,11a-tetrahydro-1H-benzochinolizin-2-(6H)-on；8,9-Dimethoxy-1,3,4,6,11,11a-hexahydro-2h-pyrido[1,2-b]isoquinolin-2-one；8,9-dimethoxy-1,3,4,6,11,11a-hexahydrobenzo[b]quinolizin-2-one
• CAS: 16675-71-1
• 化学式: C₁₅H₁₉NO₃
• 分子量: 261.321
• InChiKey: LTRGVYPKENVTPE-UHFFFAOYSA-N

物化性质

• 沸点：
  421.2±45.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8,9-dimethoxy-4,6,11,11a-tetrahydro-1H-benzoquinolizin-2(3H)-one 在 氢氧化钾 、 一水合肼 作用下， 以 various solvent(s) 为溶剂， 以50%的产率得到8,9-dimethoxy-4,6,11,11a-tetrahydro-1H-benzoquinolizine
  参考文献：
  名称：

  Dyke, Stanley F.; Spray, Clive R.; Kilminster, Raymond A., Australian Journal of Chemistry, 1983, vol. 36, # 1, p. 149 - 155

  摘要：

  DOI：

文献信息

• Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties
  作者：Guy Nadler、Jean-François Faivre、Marie-Claire Forest、Brigitte Cheval、Michel Martin、Michel Souchet、Bernard Gout、Antoine Bril

  DOI：10.1016/s0968-0896(98)00166-7

  日期：1998.11

  Class III antiarrhythmic agents have been shown to prevent reentrant arrhythmias but also to be responsible for initiating arrhythmias characterised by afterdepolarizations and triggered activities. By combining potassium and calcium channel antagonistic actions, as with BRL-32872(1,2) (1), it might be possible to reduce the incidence of proarrhythmias albeit retaining antiarrhythmic efficacy. In the present study we synthesised and tested for their electrophysiological activity in guinea pig papillary muscle a wide panel of analogues of BRL-32872. Some qualitative relationships between compound structure and the inhibitory effect on the rapidly activating component of the delayed rectifier potassium current and/or the L-type calcium current will be presented. New derivatives depicting bell-shaped dose-response curves on action potential duration may therefore represent novel agents for improved antiarrhythmic therapy. (C) 1998 Elsevier Science Ltd. All rights reserved.
• DYKE, S. F.;SPRAY, C. R.;KILMINSTER, R. A., AUSTRAL. J. CHEM., 1983, 36, N 1, 149-155
  作者：DYKE, S. F.、SPRAY, C. R.、KILMINSTER, R. A.

  DOI：——

  日期：——
• US4992446A
  申请人：——

  公开号：US4992446A

  公开（公告）日：1991-02-12
• Dyke, Stanley F.; Spray, Clive R.; Kilminster, Raymond A., Australian Journal of Chemistry, 1983, vol. 36, # 1, p. 149 - 155
  作者：Dyke, Stanley F.、Spray, Clive R.、Kilminster, Raymond A.

  DOI：——

  日期：——