1-Tert-butyl-3-thiophen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine | 577784-48-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 1-Tert-butyl-3-thiophen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
• CAS: 577784-48-6
• 化学式: C₁₃H₁₅N₅S
• 分子量: 273.362
• InChiKey: WDYBBGKIRKIQNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• MODULATION OF PROTEIN TRAFFICKING
  申请人：Bulawa Christine Ellen

  公开号：US20100331297A1

  公开（公告）日：2010-12-30

  Compounds and compositions are provided for treatment or amelioration of one or more disorders characterized by defects in protein trafficking. A method of treating a disorder characterized by impaired protein trafficking includes administering to a subject or contacting a cell with a compound of Formula I: [formula here] or pharmaceutically acceptable salts or derivatives thereof.

  本发明提供用于治疗或改善由蛋白质运输缺陷所特征的一个或多个疾病的化合物和组合物。一种治疗由蛋白质运输受损所特征的疾病的方法包括向受试者施用或与细胞接触化合物I的药物或其药学上可接受的盐或衍生物。[公式在此]
• Non-myeloablative tolerogenic treatment with tyrphostins
  申请人：——

  公开号：US20040197335A1

  公开（公告）日：2004-10-07

  A method of inducing immune tolerance in a first mammal to antigens of a second, non-syngeneic, mammal, is disclosed. The method is utilized to minimize graft rejection and/or reduce graft-versus-host diseases in transplantation procedures and to produce hematopoietic mixed chimeras. Methods of determining the activity of tyrphostins and the optimal concentration thereof in this method are also disclosed.

  本发明公开了一种诱导第一种哺乳动物对第二种非同种哺乳动物的抗原产生免疫耐受的方法。该方法可用于最大限度地减少移植过程中的移植物排斥反应和/或减少移植物抗宿主疾病，以及生产造血混合嵌合体。此外，还公开了确定酪磷脂活性的方法及其在该方法中的最佳浓度。
• EP1482983A4
  申请人：——

  公开号：EP1482983A4

  公开（公告）日：2006-07-12
• NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS
  申请人：YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM

  公开号：EP1482983A2

  公开（公告）日：2004-12-08
• [EN] NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS<br/>[FR] TRAITEMENT NON MYELOABLATIF ET TOLEROGENE PAR LES TYRPHOSTINES
  申请人：YISSUM RES DEV CO

  公开号：WO2003065971A2

  公开（公告）日：2003-08-14

  A method of inducing immune tolerance in a first mammal to antigens of a second, non-syngeneic, mammal, is disclosed. The method is utilized to minimize graft rejection and/or reduce graft-versus-host diseases in transplantation procedures and to produce hematopoietic mixed chimeras. Methods of determining the activity of tyrphostins and the optimal concentration thereof in this method are also disclosed.