E-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-propionamide | 383432-64-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: E-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-propionamide
• 英文别名: N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]propanamide
• CAS: 383432-64-2
• 化学式: C₂₇H₂₇N₅O₂
• 分子量: 453.544
• InChiKey: RQCUHRAGNNZOIZ-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  89
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
  申请人：Pfizer Products Inc.

  公开号：EP1292591B1

  公开（公告）日：2005-02-02
• Therapies for Treating Cancer Using Combinations of COX-2 Inhibitors and Antimetabolites
  申请人：Zaknoen Sara L.

  公开号：US20110301169A1

  公开（公告）日：2011-12-08

  A method for treating a subject having cancer, comprising administering to the subject, a therapeutically effective amount of a combination comprising a 1,2-diphenylpyrrole derivative or the respective pharmaceutically acceptable salt, solvate, polymorph or prodrug and an anti-metabolite.
• THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND ANTI-HER2(ERBB2) ANTIBODIES OR COMBINATIONS OF COX-2 INHIBITORS AND HER2(ERBB2) RECEPTOR TYROSINE KINASE INHIBITORS
  申请人：Estok Thomas M.

  公开号：US20120052061A1

  公开（公告）日：2012-03-01

  Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.
• METHODS AND USE OF COMPOUNDS THAT BIND TO HER2/NEU RECEPTOR COMPLEX
  申请人：Greene Mark I.

  公开号：US20130190405A1

  公开（公告）日：2013-07-25

  This application describes pharmaceutical compositions, kits, and methods for inhibiting cell proliferative disorders, especially those disorders characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, including Her2 related cancers, and methods for imaging an Her-2 expressing tumor.
• US8993634B2
  申请人：——

  公开号：US8993634B2

  公开（公告）日：2015-03-31