androst-4-ene-3,17β-diol 3,17β-di(ethylcarbonate) | 560088-20-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: androst-4-ene-3,17β-diol 3,17β-di(ethylcarbonate)
• 英文别名: [(8R,9S,10R,13S,14S,17S)-3-ethoxycarbonyloxy-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] ethyl carbonate
• CAS: 560088-20-2
• 化学式: C₂₅H₃₈O₆
• 分子量: 434.573
• InChiKey: SYGZMDRECDQCMB-AKRRWLLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Bioavailable prodrugs of androgenic steroids and related method
  申请人：——

  公开号：US20030134830A1

  公开（公告）日：2003-07-17

  A compound is provided for increasing the concentration of a parent androgen in a subject in vivo. The parent androgen has a skeletal structure including a 1 position and a 17 position, a 17&bgr;-hydroxy group comprising a 17&bgr;-hydroxy oxygen appended to the 17 position, and a 17&bgr;-hydroxy hydrogen appended to the 17&bgr;-hydroxy oxygen. The compound includes a substrate having the skeletal structure of the parent androgen. It includes a 1 position and a 17 position corresponding to the 1 and 17 positions respectively of the parent androgen. The substrate has a carbon-carbon double bond at the 1 position. The compound also has a promoiety appended to the 17&bgr;-hydroxy oxygen of the substrate as a substitute for the 17&bgr;-hydroxy hydrogen of the parent androgen. The promoiety includes, and preferably consists of, an alkylcarbonate ester. A related method also is provided.

  本发明提供了一种化合物，用于提高体内受试者体内母体雄激素的浓度。母体雄激素的骨架结构包括1位和17位，17&bgr;-羟基包括与17位相连的17&bgr;-羟基氧和与17&bgr;-羟基氧相连的17&bgr;-羟基氢。该化合物包括具有母体雄激素骨架结构的底物。它包括一个 1 位和一个 17 位，分别对应于母体雄激素的 1 位和 17 位。底物在 1 位上有一个碳碳双键。该化合物还有一个原基附加在底物的 17&bgr;-羟基氧上，以替代母体雄激素的 17&bgr;-羟基氢。原基包括，最好是烷基碳酸酯。还提供了一种相关的方法。
• Composition and method for increasing in vivo androgen concentration
  申请人：——

  公开号：US20030134828A1

  公开（公告）日：2003-07-17

  A composition is provided including a first prohormone for increasing the concentration of a Class I parent androgen in a subject in vivo, and a second prohormone for increasing the concentration of a Class II parent androgen in the subject in vivo. The first prohormone includes a first carbon-carbon double bond at the 1 position, and a first 17&bgr;-hydroxy oxygen appended to the 17 position. The first prohormone further includes a first 17-position promoiety is appended to the first 17&bgr;-hydroxy oxygen as a substitute for the 17&bgr;-hydroxy hydrogen of the Class I parent androgen. The second prohormone includes a second carbon-carbon double bond at the 4 position and a second 17&bgr;-hydroxy oxygen appended to the 17 position. The second prohormone also includes a second 17-position promoiety appended to the second 17&bgr;-hydroxy oxygen as a substitute for the 17&bgr;-hydroxy hydrogen of the Class II parent androgen.

  提供了一种组合物，其中包括用于增加体内受试者体内第一类母体雄激素浓度的第一种原激素，以及用于增加体内受试者体内第二类母体雄激素浓度的第二种原激素。第一种原激素包括位于 1 位的第一碳碳双键，以及附加到 17 位的第一 17&bgr;-羟基氧。第一种原激素还包括与第一17&bgr;-羟基氧相连的第一17位原基，作为第一类母雄激素的17&bgr;-羟基氢的替代物。第二种原激素包括位于 4 位的第二个碳碳双键和附加到 17 位的第二个 17&bgr;-羟基氧。第二种原激素还包括与第二17&bgr;-羟基氧相连的第二17位原基，作为第二类母雄激素的17&bgr;-羟基氢的替代物。
• Microemulsion composition and related method
  申请人：Roberts J. William

  公开号：US20060024341A1

  公开（公告）日：2006-02-02

  A composition for oral administration to a subject as a microemulsion. The composition includes a surfactant having a hydrophilic-lipophilic balance of between about 12 and 16, a cosurfactant having a hydrophilic-lipophilic balance of between about 5 and 6, and an active ingredient, wherein the composition comprises a microemulsion when added to water. Related compositions and methods of administration are provided as well.

  一种用于口服给药的微乳剂组合物。该组合物包括亲水-亲油平衡介于约 12 和 16 之间的表面活性剂、亲水-亲油平衡介于约 5 和 6 之间的助表面活性剂以及活性成分，其中该组合物加入水中后形成微乳液。还提供了相关的组合物和给药方法。
• US6740646B2
  申请人：——

  公开号：US6740646B2

  公开（公告）日：2004-05-25