β-naphthaldoxime hydrochloride | 1330125-02-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: β-naphthaldoxime hydrochloride
• CAS: 1330125-02-4
• 化学式: C₁₁H₉NO*ClH
• 分子量: 207.659
• InChiKey: TWJBCEAXVWWMQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  14.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  β-naphthaldoxime hydrochloride 、 methyl 2-chloro-2-[(4-fluorophenyl)hydrazinylidene]acetate;hydrochloride 在 三乙胺 作用下， 以 甲苯 为溶剂， 以28%的产率得到1-(4-fluorophenyl)-3-methoxycarbonyl-5-(2-naphthyl)-1,2,4-triazole
  参考文献：
  名称：

  An Effective Nitrilimine Cycloaddition for the Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles from Oximes with Hydrazonoyl Hydrochlorides

  摘要：

  An effective 1,3-dipolar cycloaddition for the synthesis of 1,3,5-trisubstituted 1,2,4-triazole derivatives was developed by reacting oximes with hydrazonoyl hydrochlorides using triethylamine as a base. The desired 1,3,5-trisubstituted 1,2,4-triazoles were obtained in good yields and the reaction was applicable to aliphatic, cyclic aliphatic, aromatic and heterocyclic oxime substrates.

  DOI：

  10.1055/s-0030-1260759
• 作为产物：
  描述：

  2-萘甲醛 在 盐酸羟胺 作用下， 以 甲苯 为溶剂， 生成 β-naphthaldoxime hydrochloride
  参考文献：
  名称：

  ‘One-flask’ synthesis to 3,5-disubstituted 1,2,4-triazoles from aldehydes with hydrazonoyl hydrochlorides via 1,3-dipolar cycloaddition

  摘要：

  A new 'one-flask' synthesis of 3,5-disubstituted 1,2,4-triazoles has successfully been developed to synthesize a series of 3,5-disubstituted 1,2,4-triazoles. The transformation involves the 1,3-dipolar cycloaddition reaction of hydrazonoyl hydrochlorides with oxime intermediates prepared from aldehydes with hydroxylamine hydrochloride in the presence of excess amount of triethylamine. In this 'one-flask' 1,3-dipolar reaction, hydrazonoyl hydrochlorides was concerned as the masked 1,3-dipole nitrilimine under basic condition. Furthermore, this newly developed methodology can be applied to various aldehyde substrates including aliphatic, cyclic aliphatic, aromatic, and heterocyclic aldehydes. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.003