fluoro-[7-(3-fluoro-benzyloxy)-4-oxo-4H-quinazolin-3-yl]-acetic acid ethyl ester | 713510-90-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: fluoro-[7-(3-fluoro-benzyloxy)-4-oxo-4H-quinazolin-3-yl]-acetic acid ethyl ester
• 英文别名: Ethyl 2-fluoro-2-[7-[(3-fluorophenyl)methoxy]-4-oxoquinazolin-3-yl]acetate
• CAS: 713510-90-8
• 化学式: C₁₉H₁₆F₂N₂O₄
• 分子量: 374.344
• InChiKey: XLWBZNLPPGPZSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  68.2
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] 3H-QUINAZOLIN-4-ONE DERIVATIVES<br/>[FR] DERIVES DE 3H-QUINAZOLINE-4-ONE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004054985A1

  公开（公告）日：2004-07-01

  This invention relates to 3H-quinazolin-4-one derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as selective monoamine oxidase B inhibitors.

  本发明涉及规范和声明中定义的3H-喹唑啉-4-酮衍生物，它们的制备方法，包含它们的制药组合物以及它们作为选择性单胺氧化酶B抑制剂的用途。
• 3H-quinazolin-4-one derivatives as MAO-B inhibitors
  申请人：——

  公开号：US20040142951A1

  公开（公告）日：2004-07-22

  This invention relates to 3H-quinazolin-4-one derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as selective monoamine oxidase B inhibitors.

  本发明涉及规范和要求中定义的3H-喹唑啉-4-酮衍生物，它们的制备方法，包含它们的制药组合物和它们作为选择性单胺氧化酶B抑制剂的用途。
• 3H-QUINAZOLIN-4-ONE DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1572666A1

  公开（公告）日：2005-09-14
• TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES
  申请人：Oryzon Genomics SA

  公开号：EP2195029A2

  公开（公告）日：2010-06-16
• MAO-B INHIBITORS USEFUL FOR TREATING OBESITY
  申请人：McElroy Francis John

  公开号：US20070078172A1

  公开（公告）日：2007-04-05

  The invention provides a method of treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance) in a mammal by administering to the mammal a therapeutically effective amount of an irreversible MAO-B inhibitor.