4-(2-Fluoro-4-methylsulfonylphenyl)-3-(4-fluorophenyl)-2,5-dihydro-2-furanone | 376588-53-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-(2-Fluoro-4-methylsulfonylphenyl)-3-(4-fluorophenyl)-2,5-dihydro-2-furanone
• 英文别名: 3-(4-Fluorophenyl)-4-(2-fluoro-4-methylsulfonylphenyl)-2,5-dihydro-2-furanone；3-(2-fluoro-4-methylsulfonylphenyl)-4-(4-fluorophenyl)-2H-furan-5-one
• CAS: 376588-53-3
• 化学式: C₁₇H₁₂F₂O₄S
• 分子量: 350.343
• InChiKey: QDQJUYABKLGZAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(2-Fluoro-4-methylsulfanylphenyl)-3-(4-fluorophenyl)-2,5-dihydro-2-furanone 、 Potassium;oxido hydrogen sulfite 、 丙酮 在 水 、 乙酸乙酯 、 Sodium sulfate-III 、 crude product 、 甲醇 作用下， 以 水 为溶剂， 反应 2.0h， 以to give 5.6 g of title compound in 85% yield as off white powder的产率得到4-(2-Fluoro-4-methylsulfonylphenyl)-3-(4-fluorophenyl)-2,5-dihydro-2-furanone
  参考文献：
  名称：

  Novel compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them

  摘要：

  本发明涉及一种新型杂环化合物，其一般式为(I)，其衍生物、类似物、互变异构体、立体异构体、位置异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化合物及含有它们的药学上可接受的组合物。

  公开号：

  US20020032230A1

文献信息

• Novel compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them
  申请人：DR. REDDY'S LABORATORIES LTD.

  公开号：US20020032230A1

  公开（公告）日：2002-03-14

  The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. 1

  本发明涉及一种新型杂环化合物，其一般式为（I），其衍生物，类似物，互变异构体，立体异构体，区域异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物和药学上可接受的含有它们的组合物。
• US6686390B2
  申请人：——

  公开号：US6686390B2

  公开（公告）日：2004-02-03
• [EN] NOVEL COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES POSSEDANT UNE ACTIVITE ANTI-INFLAMMATOIRE, PROCEDE DE PREPARATION DE CEUX-CI ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：REDDY RESEARCH FOUNDATION

  公开号：WO2001090097A2

  公开（公告）日：2001-11-29

  The present invention relates to novel heterocyclic compounds of general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
• Compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them
  申请人：Dr. Reddy's Laboratories Limited

  公开号：US06686390B2

  公开（公告）日：2004-02-03

  The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

  本发明涉及一类新型杂环化合物，其一般式为（I），其衍生物、类似物、互变异构体、立体异构体、区域异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂合物以及含有它们的药学上可接受的组合物。