3-(Azepan-1-yl)aniline | 141515-10-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(Azepan-1-yl)aniline
• CAS: 141515-10-8
• 化学式: C₁₂H₁₈N₂
• mdl: MFCD11132670
• 分子量: 190.28
• InChiKey: TYBMLDBFQFHCSG-UHFFFAOYSA-N

物化性质

• 沸点：
  361.2±25.0 °C(Predicted)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS<br/>[FR] DIARYLURÉES EN TANT QUE MODULATEURS ALLOSTÉRIQUES DE CB1
  申请人：RTI INT

  公开号：WO2018209030A1

  公开（公告）日：2018-11-15

  The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

  本发明提供了新颖的二芳基脲衍生物（式（I）化合物）及其用途。本发明的化合物被证明是CB1受体的变构调节剂，因此对于治疗由CB1介导的疾病和症状是有用的。
• Diarylureas as CB1 allosteric modulators
  申请人：Research Triangle Institute

  公开号：US11084781B2

  公开（公告）日：2021-08-10

  The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

  本发明提供了新型二芳脲衍生物（式（I）化合物）及其用途。本发明的化合物被证明是 CB1 受体的异位调节剂，因此可用于治疗由 CB1 介导的疾病和病症。
• DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS
  申请人：Research Triangle Institute

  公开号：EP3621951A1

  公开（公告）日：2020-03-18
• [EN] DYE COMPOSITION COMPRISING AT LEAST ONE PARTICULAR LIPOPHILIC META-PHENYLENEDIAMINE COUPLER IN A MEDIUM RICH IN FATTY SUBSTANCES, PROCESSES AND DEVICES<br/>[FR] COMPOSITION DE TEINTURE COMPORTANT AU MOINS UN COUPLEUR MÉTA-PHÉNYLÈNEDIAMINE LIPHOPHILE PARTICULIER DANS UN MILIEU RICHE EN SUBSTANCES GRASSES, PROCÉDÉS ET DISPOSITIFS
  申请人：OREAL

  公开号：WO2014118092A2

  公开（公告）日：2014-08-07

  The present invention relates to a composition for dyeing keratin fibres, comprising one or more fatty substances, one or more surfactants, one or more oxidation bases, one or more couplers of meta-phenylenediamine type with a logP of greater than or equal to 1, and one or more basifying agents, the fatty substance content in the dye composition representing in total at least 10% by weight relative to the total weight of the said composition. The invention also relates to a dyeing process using such a composition, and also to devices suitable for performing such a process.