Magnesium bis(3,12-dihydroxycholan-24-oate) | 212505-51-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Magnesium bis(3,12-dihydroxycholan-24-oate)
• 英文别名: magnesium;(4R)-4-[(3R,5R,10S,12S,13R,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
• CAS: 212505-51-6
• 化学式: C48H78MgO8
• 分子量: 807.4
• InChiKey: KVPZPSPOBQUDPV-QKECBBNCSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  5.91
• 重原子数：
  57
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Pregnane derivatives and method of producing the same
  申请人：KURARAY CO., LTD.

  公开号：EP0087787A1

  公开（公告）日：1983-09-07

  There are provided 12-hydroxy-Δ4 or Δ1.4-pregnan-3- one-20-carbaldehydes and a method of producing the same. The compounds are novel and useful as starting materials for the synthesis of corticoids, typically prednisone, prednisolone and hydrocortisone, which have antiinflammatory activity.

  本发明提供了 12-羟基-Δ4 或 Δ1.4-孕甾-3-one-20-羰基醛及其生产方法。这些化合物具有新颖性，可用作合成具有抗炎活性的皮质激素（通常为泼尼松、泼尼松龙和氢化可的松）的起始原料。
• 12-Alpha-substituted pregna-1,4-diene-3,20-diones
  申请人：KURARAY CO., LTD.

  公开号：EP0117266A1

  公开（公告）日：1984-09-05

  12a-substituted pregna-1,4-diene-3,20-dione of the general formula wherein R is a hydrogen atom, R1CO or R2SO2 where R1 is a hydrogen atom, an alkyl group which may optionally be substituted or an aryl group which may optionally be sub- stitued and R2 si an alkyl group. These compounds are useful as intermediates for the synthesis of antiinflammatory corticoids such as prednisone, prednisolone, etc..

  通式为 12a 取代的孕甾-1,4-二烯-3,20-二酮 其中 R 是氢原子、R1CO 或 R2SO2，R1 是氢原子、可选择被取代的烷基或可选择被取代的芳基，R2 si 是烷基。 这些化合物可用作合成泼尼松、泼尼松龙等抗炎皮质激素的中间体。
• Methods and related compositions for reduction of fat and skin tightening
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10058561B2

  公开（公告）日：2018-08-28

  Compositions and methods useful in the reduction of localized fat deposits and tightening of loose skin in subjects in need thereof using pharmacologically active detergents are disclosed. The pharmacologically active detergent compositions can additionally include anti-inflammatory agents, analgesics, dispersion or anti-dispersion agents and pharmaceutically acceptable excipients. The pharmacologically active detergent compositions are useful for treating localized accumulations of fat including, for example, lower eyelid fat herniation, lipodystrophy and fat deposits associated with cellulite and do not require surgical procedures such as liposuction.

  本发明公开了使用药理活性洗涤剂减少局部脂肪沉积和收紧松弛皮肤的组合物和方法。药理活性洗涤剂组合物还可包括消炎剂、镇痛剂、分散剂或抗分散剂以及药学上可接受的赋形剂。药理活性洗涤剂组合物适用于治疗局部脂肪堆积，例如下眼睑脂肪疝出、脂肪营养不良和与橘皮组织有关的脂肪沉积，而且不需要进行抽脂等外科手术。
• Microbial process for producing 12-alpha-hydroxypregna-1,4-dien-3-one-20-alpha-carboxylic acid
  申请人：KURARAY CO., LTD.

  公开号：EP0077544B1

  公开（公告）日：1986-09-10
• METHODS AND RELATED COMPOSITIONS FOR REDUCTION OF FAT AND SKIN TIGHTENING
  申请人：Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

  公开号：EP1845938A1

  公开（公告）日：2007-10-24