I+/--[[4-(Methoxycarbonyl)phenyl]methyl]-2,1,3-benzothiadiazole-5-acetic acid | 213318-86-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: I+/--[[4-(Methoxycarbonyl)phenyl]methyl]-2,1,3-benzothiadiazole-5-acetic acid
• 英文别名: 2-(2,1,3-benzothiadiazol-5-yl)-3-(4-methoxycarbonylphenyl)propanoic acid
• CAS: 213318-86-6
• 化学式: C₁₇H₁₄N₂O₄S
• 分子量: 342.4
• InChiKey: POGOKFWHPFETHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Therapeutic treatments using centhaquin
  申请人：MIDWESTERN UNIVERSITY

  公开号：US10828368B2

  公开（公告）日：2020-11-10

  Methods of treating hypertension, pain, and resuscitative hemorrhagic shock using an adrenergic agent, like centhaquin, are disclosed. The methods treat mammals, including humans.

  公开了使用肾上腺素能制剂（如仙人掌）治疗高血压、疼痛和抢救失血性休克的方法。这些方法可治疗哺乳动物，包括人类。
• Stable star-structured functional polyolefins
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US11053396B2

  公开（公告）日：2021-07-06

  Stable star-structured functional polyolefins and methods of making them, the functional polyolefins comprising a polyolefin bound at any position along its chain length to at least one nucleophile-containing silane of the following formula: wherein Y is a di- or trivalent linker group selected from heteroatoms, C1 to C10 alkylenes, and other groups disclosed herein; Nu is a nucleophilic atom or unsaturation group; R5 is selected from hydrogen, and C1 to C10 alkyls, and other groups as disclosed herein; X is a divalent group selected from linear and branched alkylenes and heteroatom-alkylenes, and other groups as disclosed herein; and PO is a polyolefin having a weight average molecular weight of at least 400 g/mole; with the proviso that at least one of R1, R2, and R3 is selected from the same or different functional polyolefin moieties. Star-structured functional polyolefins are useful as filler dispersive additives in tire formulations and processing aids.

  稳定的星形结构官能团聚烯烃及其制造方法，这种官能团聚烯烃包括在其链长的任意位置与下式中至少一种含亲核硅烷结合的聚烯烃： 其中 Y 是二价或三价连接基团，选自杂原子、C1 至 C10 烷基和本文公开的其它基团；Nu 是亲核原子或不饱和基团；R5 选自氢、C1 至 C10 烷基和本文公开的其它基团；X 是二价基团，选自直链和支链烷基和杂原子烷基，以及本文公开的其他基团； PO 是聚烯烃，其重量平均分子量至少为 400 克/摩尔；但 R1、R2 和 R3 中至少有一个选自相同或不同的功能性聚烯烃分子。星形结构官能团聚烯烃可用作轮胎配方和加工助剂中的填料分散添加剂。
• Use of endothelin receptor antogonists for the treatment of tumour diseases
  申请人：Osswald Mathias

  公开号：US20050014769A1

  公开（公告）日：2005-01-20

  Use of endothelin receptor antagonists for the preparation of a medicament for the treatment of tumour diseases.

  使用内皮素受体拮抗剂制备治疗肿瘤疾病的药物。
• METHOD AND COMPOSITION FOR TREATING DIABETIC KETOACIDOSIS
  申请人：Midwestern University

  公开号：EP2424530B1

  公开（公告）日：2015-12-16
• Method and Composition for Potentiating the Antipyretic Action of a Nonopiod Analgesic
  申请人：Gulati Anil

  公开号：US20080207763A1

  公开（公告）日：2008-08-28

  A composition and method of treating fever, and optionally treating pain, is disclosed. The composition and method utilize a nonopioid analgesic and an endothelin antagonist as active agents to treat fever in mammals, including humans. The composition also is useful in the prevention and treatment of stroke and other cardiovascular disorders, like myocardial infarction.