(3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-4,4-dimethyl-2-oxo-N-[trans-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclohexyl]-1,2-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3-pyrrolo[2,3-b]pyridine]-5'-carboxamide | 1398568-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-4,4-dimethyl-2-oxo-N-[trans-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclohexyl]-1,2-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3-pyrrolo[2,3-b]pyridine]-5'-carboxamide
• CAS: 1398568-27-8
• 化学式: C₃₂H₃₅Cl₂FN₆O₄
• 分子量: 657.572
• InChiKey: HWAZNHFAHBJJPH-UUMYXMFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.33
• 重原子数：
  45.0
• 可旋转键数：
  4.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  142.01
• 氢给体数：
  4.0
• 氢受体数：
  7.0

文献信息

• DISPIROPYRROLIDINE DERIVATIVES
  申请人：Sugimoto Yuuichi

  公开号：US20120264738A1

  公开（公告）日：2012-10-18

  A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R 1 , R 2 , R 3 , ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

  提供了一种抑制小鼠双分子2（Mdm2）蛋白与p53蛋白相互作用并具有抗肿瘤活性的化合物。本发明提供了以下式（1）所代表的二螺环吡咯烷衍生物，其具有各种取代基，抑制Mdm2蛋白与p53蛋白之间的相互作用并具有抗肿瘤活性，其中式（1）中的R1、R2、R3、环A和环B分别具有规范中定义的相同含义。
• DISPIROPYRROLIDINE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2684880A1

  公开（公告）日：2014-01-15

  A novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

  本发明提供了一种新型化合物，它能抑制小鼠双分 2（Mdm2）蛋白和 p53 蛋白之间的相互作用，并具有抗肿瘤活性。本发明提供了一种由下式（1）表示的二吡咯烷衍生物，该衍生物具有各种取代基，可抑制 Mdm2 蛋白和 p53 蛋白之间的相互作用并具有抗肿瘤活性，其中式（1）中的 R1、R2、R3、环 A 和环 B 分别具有与说明书中所定义的相同的含义。
• US8629133B2
  申请人：——

  公开号：US8629133B2

  公开（公告）日：2014-01-14