| 1417890-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1417890-22-2
• 化学式: C₃₈H₃₉N₅O₂
• 分子量: 597.76
• InChiKey: QXYNLCCBOSTRQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.76
• 重原子数：
  45.0
• 可旋转键数：
  8.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  53.31
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  1-甲基吲哚-3-甲醛 、 若丹明B酰肼 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 10.0h， 以70%的产率得到
  参考文献：
  名称：

  NIR- and FRET-Based Sensing of Cu²⁺ and S^2- in Physiological Conditions and in Live Cells

  摘要：

  We have synthesized a new indole functionalized rhodamine derivative L-1 which specifically binds to Cu2+ in the presence of large excess of other competing ions with visually observable changes in their electronic and fluorescence spectral behavior. These spectral changes are significant enough in the NIR and visible region of the spectrum and thus enable naked eye detection. The receptor, L-1, could be employed as a resonance energy transfer (RET) based sensor for detection of Cu2+ based on the process involving the donor indole and the acceptor Cu2+ bound xanthene fragment. Studies reveal that L-1-Cu complex is selectively and fully reversible in presence of sulfide anions. Further, fluorescence microscopic studies confirmed that the reagent L-1 could also be used as an imaging probe for detection of uptake of these ions in HeLa cells.

  DOI：

  10.1021/ic301872q