tert-butyl butyl{(5-formylthiophen-2-yl)methyl}carbamate | 1396517-14-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: tert-butyl butyl{(5-formylthiophen-2-yl)methyl}carbamate
• 英文别名: tert-butyl N-butyl-N-[(5-formylthiophen-2-yl)methyl]carbamate
• CAS: 1396517-14-8
• 化学式: C₁₅H₂₃NO₃S
• 分子量: 297.419
• InChiKey: CPUGZUGFNMBRMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl butylcarbamate 在 正丁基锂 、 potassium hydrogen difluoride 、 chloro (2-dicyclohexylphosphino-2 ‘,4’,6’-triisopropyl-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 、 caesium carbonate 作用下， 以 四氢呋喃 、 正己烷 、 水 、 丙酮 、 甲苯 为溶剂， 反应 3.67h， 生成 tert-butyl butyl{(5-formylthiophen-2-yl)methyl}carbamate
  参考文献：
  名称：

  Potassium Boc-Protected Secondary Aminomethyltrifluoroborates: Synthesis and Suzuki–Miyaura Cross-Coupling Reactions

  摘要：

  Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. The Suzuki-Miyaura cross-coupling reaction was studied with this new class of nucleophiles, and a large variety of aryl and hetaryl chlorides provided the desired products in good to excellent yields, thereby allowing easy access to secondary aminomethyl substructures.

  DOI：

  10.1021/ol301955s

文献信息

• Potassium Boc-Protected Secondary Aminomethyltrifluoroborates: Synthesis and Suzuki–Miyaura Cross-Coupling Reactions
  作者：Gary A. Molander、Inji Shin

  DOI：10.1021/ol301955s

  日期：2012.9.7

  Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. The Suzuki-Miyaura cross-coupling reaction was studied with this new class of nucleophiles, and a large variety of aryl and hetaryl chlorides provided the desired products in good to excellent yields, thereby allowing easy access to secondary aminomethyl substructures.