5-fluoro-N-(methoxymethyl)-N-(4-octyl-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine | 1198329-99-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-fluoro-N-(methoxymethyl)-N-(4-octyl-3-(trifluoromethyl)phenyl)-4-(pyridin-3-yl)thiazol-2-amine
• 英文别名: 5-fluoro-N-(methoxymethyl)-N-[4-octyl-3-(trifluoromethyl)phenyl]-4-pyridin-3-yl-1,3-thiazol-2-amine
• CAS: 1198329-99-5
• 化学式: C₂₅H₂₉F₄N₃OS
• 分子量: 495.584
• InChiKey: CHCUBVADMMZZNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  66.5
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Substituted Aminothiazole Prodrugs of Compounds with Anti-HCV Activity
  申请人：Liu Cuixan

  公开号：US20090304605A1

  公开（公告）日：2009-12-10

  The invention provides amino-substituted aminothiazole compounds of Formula I and Formula II where A is a group of the formula: and the variables X, Y, R, and R 1 to R 7 are described herein. These compounds are prodrugs of compounds useful as inhibitors of viral replication. Compositions containing such compounds, and methods of treating viral infections with these compounds, as well as to processes and intermediates useful for preparing such compounds are also provided by the invention.

  该发明提供了公式I和公式II的氨基取代氨噻唑化合物，其中A是以下式的基团：变量X、Y、R和R1至R7如本文所述。这些化合物是可用作抑制病毒复制的化合物的前药。该发明还提供了含有这些化合物的组合物，以及使用这些化合物治疗病毒感染的方法，以及用于制备这些化合物的过程和中间体。
• SUBSTITUTED AMINOTHIAZOLE PRODRUGS OF COMPOUNDS WITH ANTI-HCV ACTIVITY
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：EP2297143A1

  公开（公告）日：2011-03-23
• US8106209B2
  申请人：——

  公开号：US8106209B2

  公开（公告）日：2012-01-31
• [EN] SUBSTITUTED AMINOTHIAZOLE PRODRUGS OF COMPOUNDS WITH ANTI-HCV ACTIVITY<br/>[FR] AMINOTHIAZOLES SUBSTITUÉS: DES PROMÉDICAMENTS DE COMPOSÉS DOTÉS D'UNE ACTIVITÉ ANTI-VHC
  申请人：ACHILLION PHARMACEUTICALS INC

  公开号：WO2009149436A1

  公开（公告）日：2009-12-10

  The invention provides amino-substituted aminothiazole compounds of Formula (I) and Formula (II) where A is a group of the formula: and the variables X, Y, R, and R1 to R7 are described herein. These compounds are prodrugs of compounds useful as inhibitors of viral replication. Compositions containing such compounds, and methods of treating viral infections with these compounds, as well as to processes and intermediates useful for preparing such compounds are also provided by the invention.