8α-hydroxy-9-epi-4,6,11-tri-O-methyl-ζ-rhodomycinone | 75332-03-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: 8α-hydroxy-9-epi-4,6,11-tri-O-methyl-ζ-rhodomycinone
• CAS: 75332-03-5
• 化学式: C₂₅H₂₆O₉
• 分子量: 470.476
• InChiKey: SXQBRJYOASDRNO-XZLBEJRYSA-N

反应信息

• 作为产物：
  描述：

  8,9-dehydro-9-epi-4,6,11-tri-O-methyl-ζ-rhodomycinone 8,9-epoxide 在 高氯酸 作用下， 以 丙酮 为溶剂， 反应 64.0h， 以18%的产率得到8α-hydroxy-9-epi-4,6,11-tri-O-methyl-ζ-rhodomycinone
  参考文献：
  名称：

  8-Hydroxyanthracyclinones from .epsilon.-rhodomycinone

  摘要：

  epsilon-Rhodomycinone was converted into 8,9-dehydro-zeta-rhodomycinone, which gave a cis diol with osmium tetroxide and a pair of epimeric epoxides with m-chloroperbenzoic acid. Acid-catalyzed opening of the epoxides gave the corresponding trans diols. In contrast, acid treatment of the trimethyl ethers of these epoxides gave predominantly a lactone and an eta-rhodomycinone derivative, with only small amounts of the diols. None of the new rhodomycinones were active against Bacillus subtilis, but 8,9-dehydro-zeta-rhodomycinone was active in the induction of lytic phage in Escherichia coli.

  DOI：

  10.1021/jm00185a020