(1S)-1-[(3R,5S)-3-allyl-3-isobutylisoxazolidin-5-yl]-2-(tert-butyldimethylsilanyloxy)ethanol | 866483-35-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (1S)-1-[(3R,5S)-3-allyl-3-isobutylisoxazolidin-5-yl]-2-(tert-butyldimethylsilanyloxy)ethanol
• CAS: 866483-35-4
• 化学式: C₁₈H₃₇NO₃Si
• 分子量: 343.582
• InChiKey: UMRNNDCGCKUXFH-BQFCYCMXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.02
• 重原子数：
  23.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  50.72
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (1S)-1-[(3R,5S)-3-allyl-3-isobutylisoxazolidin-5-yl]-2-(tert-butyldimethylsilanyloxy)ethanol 在 sodium tetrahydroborate 、 sodium periodate 、 四氧化锇 、 N-甲基吲哚酮 、 四丁基氟化铵 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 、 叔丁醇 为溶剂， 反应 36.03h， 生成 4-[(3R,5S)-2-benzyl-3-(2-hydroxyethyl)-3-isobutylisoxazolidin-5-ylmethylenehydrazinocarbonyl]-2-{4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoylamino}-(S)-butyric acid
  参考文献：
  名称：

  Stereochemical Promiscuity in Artificial Transcriptional Activators

  摘要：

  Small molecule replacements of transcriptional activation domains are highly desirable targets due to their utility as mechanistic tools and their long-term therapeutic potential for a variety of human diseases. Here, we examine the ability of amphipathic isoxazolidines differing only in the placement of constituent side chains to function as transcriptional activation domains. The results reveal that precise positioning of functional groups within a conformationally constrained small molecule scaffold is not required for transcription function; rather, the balance of polarity and hydrophobicity within the scaffold is the more important determinant of transcription function. This suggests that a number of different organic molecule scaffolds should function as transcriptional activator domains when appropriately functionalized, a hypothesis currently under investigation.

  DOI：

  10.1021/ja0536567
• 作为产物：
  描述：

  2-(tert-butyldimethylsilanyloxy)-(1S)-1-[(5S)-3-isobutyl-4,5-dihydroisoxazol-5-yl]ethanol 、 氯丙烯镁 在 三氟化硼乙醚 作用下， 以 甲苯 、 四氢呋喃 为溶剂， 反应 6.5h， 以300 mg的产率得到(1S)-1-[(3R,5S)-3-allyl-3-isobutylisoxazolidin-5-yl]-2-(tert-butyldimethylsilanyloxy)ethanol
  参考文献：
  名称：

  Stereochemical Promiscuity in Artificial Transcriptional Activators

  摘要：

  Small molecule replacements of transcriptional activation domains are highly desirable targets due to their utility as mechanistic tools and their long-term therapeutic potential for a variety of human diseases. Here, we examine the ability of amphipathic isoxazolidines differing only in the placement of constituent side chains to function as transcriptional activation domains. The results reveal that precise positioning of functional groups within a conformationally constrained small molecule scaffold is not required for transcription function; rather, the balance of polarity and hydrophobicity within the scaffold is the more important determinant of transcription function. This suggests that a number of different organic molecule scaffolds should function as transcriptional activator domains when appropriately functionalized, a hypothesis currently under investigation.

  DOI：

  10.1021/ja0536567