2-chloro-3-(9-cyclopropyl-8-oxo-8,9-dihydro-3H-3,4,9-triaza-cyclopenta[a]naphthalen-7-yl)-N-ethyl-5-methoxy-benzamide | 958229-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-chloro-3-(9-cyclopropyl-8-oxo-8,9-dihydro-3H-3,4,9-triaza-cyclopenta[a]naphthalen-7-yl)-N-ethyl-5-methoxy-benzamide
• 英文别名: 2-chloro-3-(1-cyclopropyl-2-oxo-7H-pyrrolo[2,3-h][1,6]naphthyridin-3-yl)-N-ethyl-5-methoxybenzamide
• CAS: 958229-82-8
• 化学式: C₂₃H₂₁ClN₄O₃
• 分子量: 436.898
• InChiKey: GUVLBKYPKQYAJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  87.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHBITORS
  申请人：Ren Pingda

  公开号：US20100048552A1

  公开（公告）日：2010-02-25

  The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bcr-Abl(T315I), ALK, BLK, BMX, BRK, C-kit, c-RAF, CSK, c-SRC, EGFR, Fes, FGFR3, Flt3, Fms, Fyn, IGF-1R, IR, JAK(2), JAK(3), KDR, Lck, NLK, p70S6K, PDGFRα, Ros, SAPK2α, SGK, SIK, Syk, Tie2 and TrkB kinases.

  本发明提供了一类新型化合物，包括含有这种化合物的药物组合物以及使用这种化合物治疗或预防与异常或非正常激酶活性相关的疾病或失调的方法，特别是那些涉及到Abl、Bcr-Abl、Bcr-Abl(T315I)、ALK、BLK、BMX、BRK、C-kit、c-RAF、CSK、c-SRC、EGFR、Fes、FGFR3、Flt3、Fms、Fyn、IGF-1R、IR、JAK(2)、JAK(3)、KDR、Lck、NLK、p70S6K、PDGFRα、Ros、SAPK2α、SGK、SIK、Syk、Tie2和TrkB激酶的异常激活的疾病或失调。
• COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
  申请人：IRM LLC

  公开号：EP2027123B1

  公开（公告）日：2011-02-23
• US7846923B2
  申请人：——

  公开号：US7846923B2

  公开（公告）日：2010-12-07
• [EN] COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS<br/>[FR] COMPOSÉS INHIBITEURS DE PROTÉINES KINASES ET COMPOSITIONS COMPRENANT DE TELS COMPOSÉS
  申请人：IRM LLC

  公开号：WO2007134259A2

  公开（公告）日：2007-11-22

  [EN] The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr-Abl, Bcr-Abl(T315I), ALK5BLK, BMX, BRK, C-kit, c-RAF, CSK, c-SRC, EGFR, Fes, FGFR3, Flt3, Fms, Fyn, IGF-IR, IR, JAK(2), JAK(3), KDR, Lck, NLK, p70S6K, PDGFRa, Ros, SAPK2a, SGK, SIK, Syk, Tie2 and TrkB kinases.
  [FR] L'invention concerne une nouvelle classe de composés, des compositions pharmaceutiques comprenant de tels composés et des procédés d'utilisation de tels composés pour traiter ou prévenir des maladies ou des troubles associés à une activité anormale ou dérégulée de kinases, en particulier des maladies ou des troubles qui impliquent une activation anormale des kinases AbI, Bcr-Abl, Bcr-Abl(T315I), ALK5BLK, BMX, BRK, C-kit, c-RAF, CSK, c-SRC, EGFR, Fes, FGFR3, Flt3, Fms, Fyn, IGF-IR, IR, JAK(2), JAK(3), KDR, Lck, NLK, p70S6K, PDGFRa, Ros, SAPK2a, SGK, SIK, Syk, Tie2 et TrkB.