Methanaminium, N,N,N-trimethyl-, carbonate (2:1) | 40105-52-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Methanaminium, N,N,N-trimethyl-, carbonate (2:1)
• 英文别名: tetramethylazanium;carbonate
• CAS: 40105-52-0
• 化学式: C9H24N2O3
• 分子量: 208.3
• InChiKey: WJZPIORVERXPPR-UHFFFAOYSA-L

物化性质

• 沸点：
  >100 °C
• 密度：
  1.041 g/mL at 25 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R34
• 危险品运输编号：
  UN 3267 8/PG 3

文献信息

• Process for preparing 4-aminodiphenylamine
  申请人：Wang Nongyue

  公开号：US20050065376A1

  公开（公告）日：2005-03-24

  The present invention discloses a process for preparing 4-aminodiphenylamine, which process uses nitrobenzene and aniline as raw materials, a complex base catalyst as condensation catalyst and a powdery composite catalyst as hydrogenation catalyst, and comprises five process stages: condensation; separation I; hydrogenation; separation II; and refining. The process can be continuously carried out. By selecting a complex base catalyst to catalyze the condensation reaction and separating it prior to the hydrogenation, the problem that the complex base catalysts thermally decompose in the hydrogenation reaction is avoided, the selectable range of hydrogenation catalysts is largely enlarged so that it is possible to select cheaper hydrogenation catalyst, and the selection of production process and equipment is easier and further industrialization is easier. The complex base catalysts used in the present invention are inexpensive and have higher catalytic activity. The process can be carried out at mild conditions and can adapt to broad range of water content, by-product is less and conversion and selectivity are higher. The operational strength is low, no corrosive liquid is produced, and environment pollution is reduced. The purity of 4-aminodiphenylamine prepared can exceed 99 wt.-%, and the yield in the industrial production process can be over 95%.

  本发明公开了一种制备4-氨基二苯胺的方法，该方法使用硝基苯和苯胺作为原料，复合碱基催化剂作为缩合催化剂，粉状复合催化剂作为加氢催化剂，并包括五个工艺阶段：缩合；分离I；加氢；分离II；和精制。该方法可以连续进行。通过选择复合碱基催化剂催化缩合反应并在加氢之前分离它，避免了复合碱基催化剂在加氢反应中热分解的问题，大大扩大了可选择的加氢催化剂范围，从而可以选择更便宜的加氢催化剂，并且生产工艺和设备的选择更容易，进一步工业化更容易。本发明中使用的复合碱基催化剂价格低廉且具有较高的催化活性。该方法可以在温和条件下进行，并且可以适应广泛的含水量范围，副产物较少，转化率和选择性较高。操作强度低，不产生腐蚀性液体，减少了环境污染。制备的4-氨基二苯胺的纯度可以超过99重量％，工业生产过程中的产率可以超过95％。
• [EN] ANTIBACTERIAL BIAROMATIC DERIVATIVES WITH OXETANE-3-YLOXY SUBSTITUTION<br/>[FR] DÉRIVÉS BIAROMATIQUES ANTIBACTÉRIENS AVEC SUBSTITUTION PAR OXÉTANE-3-YLOXY
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2017179002A1

  公开（公告）日：2017-10-19

  The invention relates to antibacterial compounds of formula (I), wherein U1 represents N or CH, U2 represents N or CH, U3 represents N or CH, it being understood that at most two of U1, U2, U3 can represent N at the same time; V1 represents N or CH, V2 represents N, CH or C(OH) and V3 represents N, CH or C(OH), it being understood that at most two of V1, V2 and V3 can represent N at the same time; the dotted line "----- " represents a bond or is absent; X represents CH or N; and Q represents O or S. It further relates pharmaceutical compositions containing these compounds and the uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections. These compounds are useful antimicrobial agents effective against a variety of human and veterinary pathogens including among others Gram-positive and Gram-negative aerobic and anaerobic bacteria.

  本发明涉及具有公式(I)的抗菌化合物，其中U1代表N或CH，U2代表N或CH，U3代表N或CH，理解为一共最多有两个U1、U2、U3可以同时代表N；V1代表N或CH，V2代表N、CH或C(OH)，V3代表N、CH或C(OH)，理解为一共最多有两个V1、V2和V3可以同时代表N；虚线“-----”代表一个键或不存在；X代表CH或N；Q代表O或S。它还涉及包含这些化合物的药物组合物，以及这些化合物在制造用于治疗细菌感染的药物中的应用。这些化合物是有用的抗菌剂，对包括革兰氏阳性菌和革兰氏阴性菌在内的多种人类和兽医病原体有效。
• Glutamate receptor photomodulators
  申请人：Consejo Superior De Investigaciones Científicas

  公开号：EP2853565A1

  公开（公告）日：2015-04-01

  The present invention relates to the discovery of particular aromatic compounds of formula (1), possessing activity as modulators of metabotropic glutamate receptors (mGIuR) whose modulatory activity on the receptor may be controlled by irradiation with suitable light resulting in the optical control of receptor biological function, to the use of said compounds as a medicament, and to pharmaceutical compositions comprising said compounds of formula (1).

  本发明涉及发现具有公式（1）的特定芳香化合物，其具有作为代谢型谷氨酸受体（mGluR）调节剂的活性，其对受体的调节活性可以通过适当光照的照射来控制，从而实现对受体生物功能的光控制，以及将所述化合物用作药物的用途，以及包含公式（1）中所述化合物的药物组合物。
• [EN] ANTIBACTERIAL BASIC BIAROMATIC DERIVATIVES WITH AMINOALKOXY SUBSTITUTION<br/>[FR] DÉRIVÉS BI-AROMATIQUES DE BASE ANTIBACTÉRIENS AVEC SUBSTITUTION AMINOALCOXY
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2016059097A1

  公开（公告）日：2016-04-21

  The invention relates to antibacterial compounds of formula I wherein R1a, R2a, R2b, R3a, R3b, R4, R5, U1, U2, U3, U4, V1, V2, V3, V4, X and Q and n are as defined in the specification. It further relates pharmaceutical compositions containing these compounds and the uses of these compounds in the manufacture of medicaments for the treatment of bacterial infections. These compounds are useful antimicrobial agents effective against a variety of human and veterinary pathogens including among others Gram-positive and Gram-negative aerobic and anaerobic bacteria.

  该发明涉及式I的抗菌化合物，其中R1a、R2a、R2b、R3a、R3b、R4、R5、U1、U2、U3、U4、V1、V2、V3、V4、X和Q以及n如规范中所定义。它进一步涉及含有这些化合物的药物组合物，以及这些化合物在制造用于治疗细菌感染的药物品的用途。这些化合物是有用的抗微生物剂，对包括革兰氏阳性和阴性厌氧细菌在内的各种人类和兽医病原体具有有效作用。
• [EN] ANTIBACTERIAL BIAROMATIC DERIVATIVES<br/>[FR] DÉRIVÉS BI-AROMATIQUES ANTIBACTÉRIENS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2014170821A1

  公开（公告）日：2014-10-23

  The invention relates to antibacterial compounds of formula I (I) wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (l-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-l-yl or 3,4-dihydroxycyclopentyl)methoxy; U1 is N or CR1, U2 is N or CR2, U3 is N or CR3 and U4 is N or CR4, it being understood that at most three of U1, U2, U3 and U4 can be N at the same time; V1 is N or CR5, V2 is N or CR6, V3 is N or CR7 and V4 is N or CH, it being understood that at most two of V1, V2, V3 and V4 can be N at the same time; R1 is H, cyano, hydroxy or alkoxy; R2 is H, hydroxy or alkoxy; R3 is H, cyano, hydroxy, alkoxy or carboxamido; R4 is H or alkoxy; R5 is H, hydroxy or halogen; R6 is H, hydroxy or halogen; R7 is H; the dotted line "_____ " represents a bond or is absent; W represents CH or N when the dotted line "_____ " is a bond, or W represents CH2 when the dotted line "_____ " is absent; X represents CH or N; and Q represents O or S; and salts thereof.

  该发明涉及公式I（I）的抗菌化合物，其中R是H、氰基、烷氧基、氰甲氧基、环烷基甲氧基、羟基烷氧基、烷氧基烷氧基、烷氧基羰基、2-乙氧基-2-氧基乙氧基、2-(甲基氨基)-2-氧基乙氧基、(1-氰基环丁基)甲氧基、3-羟基吡咯烷-1-基或3,4-二羟基环戊基)甲氧基；U1是N或CR1，U2是N或CR2，U3是N或CR3，U4是N或CR4，理解为U1、U2、U3和U4中最多有三个可以同时为N；V1是N或CR5，V2是N或CR6，V3是N或CR7，V4是N或CH，理解为V1、V2、V3和V4中最多有两个可以同时为N；R1是H、氰基、羟基或烷氧基；R2是H、羟基或烷氧基；R3是H、氰基、羟基、烷氧基或羧胺基；R4是H或烷氧基；R5是H、羟基或卤素；R6是H、羟基或卤素；R7是H；虚线"_____"代表键或不存在；W代表CH或N，当虚线"_____"为键时，或W代表CH2，当虚线"_____"不存在时；X代表CH或N；Q代表O或S；及其盐。