4-chloro-1-methyl-isoquinoline | 1190769-77-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-chloro-1-methyl-isoquinoline
• 英文别名: 4-Chloro-1-methylisoquinoline
• CAS: 1190769-77-7
• 化学式: C₁₀H₈ClN
• 分子量: 177.633
• InChiKey: ULAROEBYOYVVRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-Chloro-1-methyl-1,4-dihydroisoquinoline 在 甲醇 、 air 作用下， 以 乙醚 为溶剂， 反应 0.5h， 生成 4-chloro-1-methyl-isoquinoline
  参考文献：
  名称：

  Direct 1,4-difunctionalization of isoquinoline

  摘要：

  The synthesis of 1,4-disubstituted isoquinoline derivatives was achieved in one step starting from isoquinoline. The process involved a nucleophilic addition in 1-position followed by an electrophilic trapping in 4-position. Interesting features were noted when C2Cl6 was used as the electrophile since different compounds could be isolated selectively only by adjusting the reaction parameters. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.125

文献信息

• Hepatitis C Virus Inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US20130183269A1

  公开（公告）日：2013-07-18

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

  本公开涉及抗病毒化合物，更具体地涉及能够抑制丙型肝炎病毒（HCV）编码的NS5A蛋白功能的化合物组合，包括这种组合的组成物，以及抑制NS5A蛋白功能的方法。
• [EN] FLUORINE-CONTAINING ORGANOSULFUR COMPOUND AND PESTICIDAL COMPOSITION THEREOF<br/>[FR] COMPOSÉ ORGANOSULFURÉ FLUORÉ ET COMPOSITION PESTICIDE EN CONTENANT
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2009025397A1

  公开（公告）日：2009-02-26

  There is provided a fluorine-containing organosulfur compound having an excellent control effect on harmful arthropods, which is represented by the formula (I): wherein m represents 0 or 1; n represents 0, 1 or 2; A represents an optionally substituted 6-membered aromatic heterocyclic group; R1 to R4 are the same or different and represent a hydrogen atom, a C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and Q represents a C1-C5 haloalkyl group containing at least one fluorine atom, or a fluorine atom.

  提供了一种含氟有机硫化合物，对有害节肢动物具有优异的控制效果，其化学式表示为(I)：其中，m表示0或1；n表示0、1或2；A表示可选取代的6元芳香杂环基团；R1到R4相同或不同，表示氢原子，C1-C4链烃基，在其中可选地取代卤素原子等；Q表示至少含有一个氟原子的C1-C5卤代烷基，或氟原子。
• COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3019196B1

  公开（公告）日：2018-06-06
• FLUORINE-CONTAINING ORGANOSULFUR COMPOUND AND PESTICIDAL COMPOSITION THEREOF
  申请人：Kumamoto Koji

  公开号：US20110124651A1

  公开（公告）日：2011-05-26

  There is provided a fluorine-containing organosulfur compound having an excellent control effect on harmful arthropods, which is represented by the formula (I): wherein m represents 0 or 1; n represents 0, 1 or 2; A represents an optionally substituted 6-membered aromatic heterocyclic group; R 1 to R 4 are the same or different and represent a hydrogen atom, a C1-C4 chain hydrocarbon group optionally substituted with a halogen atom, etc.; and Q represents a C1-C5 haloalkyl group containing at least one fluorine atom, or a fluorine atom.
• N-BICYCLIC ARYL,N'-PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
  申请人：ARRAY BIOPHARMA INC.

  公开号：US20160280681A1

  公开（公告）日：2016-09-29

  Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.