3-(5-tert-butyl-4-hydroxy-3-methylphenyl)propanoic acid | 24794-55-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(5-tert-butyl-4-hydroxy-3-methylphenyl)propanoic acid
• 英文别名: 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionic acid；β-(5-tert-butyl-4-hydroxy-3-methylphenyl)propionic acid；3-(3'-t-butyl-5'-methyl-4'-hydroxyphenyl)propionic acid；2-tert-Butyl-4-(2-carboxyethyl)-6-methylphenol；3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propanoic acid
• CAS: 24794-55-6
• 化学式: C₁₄H₂₀O₃
• 分子量: 236.311
• InChiKey: FLZYQMOKBVFXJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(5-tert-butyl-4-hydroxy-3-methylphenyl)propanoic acid 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 3.0h， 生成 β-(3-tert-butyl-5-methyl-4-hydroxyphenyl)propanoyl chloride
  参考文献：
  名称：

  具有位阻酚的低聚乙二醇杂化物的指示剂性能

  摘要：

  由在末端羟基上用位阻酚改性的聚乙二醇形成的杂化化合物（共轭物）的水溶液在一定温度下会失去其相稳定性，这取决于聚乙二醇的分子量，位阻酚的结构，共轭物的浓度和介质的组成。该性质可用于估计结构因素对缀合物-水系统中的疏水-亲水平衡的影响。

  DOI：

  10.1134/s1070428014030129

文献信息

• MULTIFUNCTIONAL SMALL MOLECULES
  申请人：The Regents of the University of Michigan

  公开号：US20150216993A1

  公开（公告）日：2015-08-06

  The present invention relates to novel therapeutic dendrimer conjugates configured for the treatment and/or prevention of organophosphate poisoning. In particular, the present invention is directed to dendrimers complexed with organophosphate poisoning antidotes (e.g., pralidoxime (2-PAM) (4-PAM), obidoxime, trimedoxime, asoxime (HI-6), hydroxamate, and related analogs, salts and derivatives thereof), compositions comprising such dendrimer conjugates, related methods of synthesizing such dendrimer conjugates, as well as systems and methods utilizing such dendrimer conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in the treatment and/or prevention of organophosphate poisoning)).

  本发明涉及用于治疗和/或预防有机磷酸盐中毒的新型治疗性树状大分子偶联物。特别是，本发明涉及与有机磷酸盐中毒解毒剂（例如，普瑞洛霉素（2-PAM）（4-PAM），奥比多西姆，三甲多西姆，阿索西姆（HI-6），羟基酰胺以及相关的类似物，盐和衍生物）复合的树状大分子，包含这样的树状大分子偶联物的组合物，合成这样的树状大分子偶联物的方法，以及利用这样的树状大分子偶联物（例如，在诊断和/或治疗环境中（例如，用于治疗剂，成像和/或靶向剂（例如，在治疗和/或预防有机磷酸盐中毒）的递送））的系统和方法。
• [EN] STERICALLY HINDERED AMINE STABILIZERS<br/>[FR] STABILISANTS D'AMINES À ENCOMBREMENT STÉRIQUE
  申请人：BASF SE

  公开号：WO2010142572A1

  公开（公告）日：2010-12-16

  The instant invention pertains to hindered amine compounds having at least two nitrogen atoms with different basicity. One part is substituted on the N-atom by alkoxy moieties and the other part is substituted on the N-atom by a hydroxy-alkyl moiety. These materials are particularly effective in stabilizing polymers, especially thermoplastic polyolefins, against the deleterious effects of oxidative, thermal and actinic radiation. The compounds are also particularly effective in stabilizing acid catalyzed and ambient cured coatings systems.

  这项瞬时发明涉及具有至少两个氮原子且碱度不同的受阻胺化合物。其中一部分在N原子上被烷氧基团取代，另一部分在N原子上被一个羟基-烷基基团取代。这些材料在稳定聚合物方面特别有效，尤其是热塑性聚烯烃，可以抵御氧化、热和光辐射的有害影响。这些化合物在稳定酸催化和环境固化的涂层系统方面也特别有效。
• [EN] LIQUID PHOSPHITE COMPOSITION DERIVED FROM META-CRESOLS<br/>[FR] COMPOSITION LIQUIDE DE PHOSPHITES ISSUE DE MÉTA-CRÉSOLS
  申请人：CHEMTURA CORP

  公开号：WO2011014211A1

  公开（公告）日：2011-02-03

  A composition at least two different phosphites, one of which is derived from an alkylated m-cresol, wherein the composition is a liquid at ambient conditions. The other phosphites may be derived from alkylated cresol, alkylated phenol or other alkylated hydroxyaryl compounds. The cresol may be mono-alkylated or di-alkylated with a C1-C18 alkyl group.

  一种至少含有两种不同亚磷酸盐的组成物，其中一种来自烷基化间甲酚，该组成物在常温常压下为液态。其他亚磷酸盐可以来自烷基化甲酚、烷基化酚或其他烷基化羟基芳香族化合物。甲酚可以是单烷基化或二烷基化，并具有C1-C18烷基基团。
• 4-Formyl amino-n-methylpiperidine derivatives, the use thereof as stabilisers and organic material stabilised therewith
  申请人：——

  公开号：US20030083406A1

  公开（公告）日：2003-05-01

  The present invention relates to 4-formylamino-N-methylpiperidine derivatives of the formula (I) 1 where the variables are as defined in the Description, to a process for preparing these piperidine derivatives, to the use of these piperidine derivatives of the invention, or prepared according to the invention, for stabilizing organic material, in particular for stabilizing plastics or coating materials, and also to the use of these piperidine derivatives of the invention, or prepared according to the invention, as light stabilizers or stabilizers for wood surfaces. The present invention further relates to stabilized organic material which comprises these piperidine derivatives of the invention or prepared according to the invention.

  本发明涉及通式(I)的4-甲酰氨基-N-甲基哌啶衍生物 1 其中变量如说明书中所定义，涉及制备这些哌啶衍生物的方法，涉及这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物用于稳定有机材料，特别是用于稳定塑料或涂料材料，还涉及这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物作为光稳定剂或木材表面的稳定剂的使用。 本发明还涉及包含这些本发明的哌啶衍生物或按照本发明制备的哌啶衍生物的稳定有机材料。
• N-Allyl/benzyl substituted phenylenediamine stabilizers
  申请人：CIBA-GEIGY AG

  公开号：EP0538195A2

  公开（公告）日：1993-04-21

  Compositions are described which comprise (a) a lubricant, subject to oxidative or thermal degradation, and (b) at least one compound of formula I wherein    R⁵, R⁶, R⁷ and R⁸ are independently hydrogen, alkenyl of 3 to 18 carbon atoms, aralkyl of 7 to 15 carbon atoms, aryl of 6 to 10 carbon atoms or said aryl substituted by one to three substituents selected from the group consisting of alkyl of 1 to 20 carbon atoms, cycloalkyl of 5 to 12 carbon atoms, aralkyl of 7 to 15 carbon atoms, -CN, -NO⁶, halogen, -ORψ, -NR¼R½, -SR¾, -COOR| and -CONR⁵⁴R⁵⁵ where Rψ, R¼, R½, R¾, R|, R⁵⁴ and R⁵⁵ are independently hydrogen, alkyl of 1 to 20 carbon atoms, alkenyl of 3 to 18 carbon atoms, aryl of 6 to 10 carbon atoms, cycloalkyl of 5 to 12 carbon atoms or aralkyl of 7 to 15 carbon atoms. Some of the compounds of formula one are novel.

  描述了以下组成的组合物： (a) 一种润滑剂，容易受到氧化或热降解，和 (b) 至少一个公式 I 的化合物 其中 R⁵, R⁶, R⁷ 和 R⁸ 分别独立为氢，3至18碳原子的烯基，7至15碳原子的芳基烷基，6至10碳原子的芳基或所述芳基被1至3个选自以下组的取代基所取代：1至20碳原子的烷基，5至12碳原子的环烷基，7至15碳原子的芳基烷基，-CN, -NO⁶, 卤素，-ORψ, -NR¼R½, -SR¾, -COOR| 和 -CONR⁵⁴R⁵⁵，其中 Rψ, R¼, R½, R¾, R|, R⁵⁴ 和 R⁵⁵ 分别独立为氢，1至20碳原子的烷基，3至18碳原子的烯基，6至10碳原子的芳基，5至12碳原子的环烷基或7至15碳原子的芳基烷基。 公式 I 中的某些化合物是新颖的。