7-(2-Benzyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-7-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester | 1192506-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-(2-Benzyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-7-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester
• 英文别名: 7-(2-benzyl-1,2,3,4,6,8a-hexahydro-pyrrolo[1,2S-a]pyrazin-7-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester；ethyl 7-(2-benzyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-7-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate
• CAS: 1192506-32-3
• 化学式: C₃₁H₂₅F₃N₄O₃
• 分子量: 558.56
• InChiKey: GMHJUBQHYALUJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
  申请人：Macielag Mark J.

  公开号：US20090270379A1

  公开（公告）日：2009-10-29

  The present invention is directed to quinolone derivatives, useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said derivatives and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes

  本发明涉及喹诺酮衍生物，作为抗微生物化合物有用，包括所述衍生物的药物组合物以及所述衍生物和药物组合物作为抗病原微生物的抗微生物剂的用途，特别是对抗耐药微生物。
• [EN] QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS DE QUINOLONE UTILES EN TANT QU'AGENTS ANTIBACTÉRIENS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009131973A1

  公开（公告）日：2009-10-29

  The present invention is directed to quinolone derivatives of formula (I), useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said derivatives and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes when Ro is selected from the group consisting of formula (a) (b) and (c).