1-propionylamino-1,2,3,4-tetrahydronaphthalene | 1235234-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-propionylamino-1,2,3,4-tetrahydronaphthalene
• 英文别名: N-(1,2,3,4-tetrahydronaphthalen-1-yl)propanamide
• CAS: 1235234-15-7
• 化学式: C₁₃H₁₇NO
• mdl: MFCD20504046
• 分子量: 203.284
• InChiKey: LGJZXTSRRXADSU-UHFFFAOYSA-N

物化性质

• 沸点：
  398.1±22.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE<br/>[FR] SULFONAMIDOPROPIONAMIDES SUBSTITUES ET PROCEDES D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2006036664A1

  公开（公告）日：2006-04-06

  This invention is in the field of pharmaceutical agents and specifically relates to compounds, compositions, uses and methods for treating inflammation-related disorders, including pain.

  这项发明属于药物代理领域，具体涉及化合物、组合物、用途和治疗与炎症相关的疾病，包括疼痛的方法。
• [EN] TETRALINE SULFONAMIDE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS<br/>[FR] DÉRIVÉS DE SULFONAMIDE DE TÉTRALINE POUR L'UTILISATION DANS LE TRAITEMENT DE TROUBLES DE PROLIFÉRATION
  申请人：UNIV NOTRE DAME DE LA PAIX

  公开号：WO2012175654A1

  公开（公告）日：2012-12-27

  Tetraline sulfonamides derivatives highly specific towards CA IX and/or CA XII human carbonic anhydrase for targeting solid tumors.

  四环磺胺衍生物对人类碳酸酐酶CA IX和/或CA XII具有高度特异性，用于靶向固体肿瘤。
• N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands
  申请人：Leopoldo Marcello

  公开号：US20070117811A1

  公开（公告）日：2007-05-24

  A series of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides was prepared and their affinity for serotonin 5-HT 7 , 5-HT 1A , and 5-HT 2A receptors was measured using in vitro binding assays. In relation to 5-HT 7 receptor affinity, receptor binding studies indicated that: (i) the optimal alkyl chain length was five methylenes; (ii) an unsubstituted 1,2,3,4-tetrahydronaphthalenyl nucleus was selected for further substitutions; and (iii) the substitution pattern of the aryl ring linked to the piperazine ring played a significant role. Several compound with high affinity for 5-HT 7 receptors were identified. Among them, 4-(2-methoxyphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide (28), 4-(2-acetylphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide (34), 4-(2-methylthiophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide (44), 4-(2-hydroxyphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide (46), 4-(2-methylphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide (49) were assayed for the 5-HT 7 receptor mediated relaxation of substance P-induced guinea-pig ileum contraction. Compounds 28, 44, and 49 behaved as full agonists, compound 34 as a partial agonist, whereas derivative 46 acted as an antagonist.

  一系列N-(1,2,3,4-四氢萘基)-4-芳基-1-哌嗪烷基酰胺被制备，并利用体外结合实验测定它们对5-HT7、5-HT1A和5-HT2A受体的亲和力。关于5-HT7受体亲和力，受体结合研究表明：(i) 最佳的烷基链长度为五个亚甲基；(ii) 选择未取代的1,2,3,4-四氢萘基核进行进一步取代；(iii) 与哌嗪环相连的芳基环的取代模式起着重要作用。鉴定了几种对5-HT7受体具有高亲和力的化合物。其中，4-(2-甲氧基苯基)-N-(1,2,3,4-四氢萘基)-1-哌嗪己酰胺（28）、4-(2-乙酰基苯基)-N-(1,2,3,4-四氢萘基)-1-哌嗪己酰胺（34）、4-(2-甲硫基苯基)-N-(1,2,3,4-四氢萘基)-1-哌嗪己酰胺（44）、4-(2-羟基苯基)-N-(1,2,3,4-四氢萘基)-1-哌嗪己酰胺（46）、4-(2-甲基苯基)-N-(1,2,3,4-四氢萘基)-1-哌嗪己酰胺（49）被用于评估对5-HT7受体介导的物质P诱导的豚鼠回肠收缩的松弛作用。化合物28、44和49表现为全激动剂，化合物34表现为部分激动剂，而衍生物46表现为拮抗剂。
• METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISORDERS
  申请人：Moran Magdalene M.

  公开号：US20120046305A1

  公开（公告）日：2012-02-23

  Compounds and compositions for treating disorders related to TRPA1 are described herein.

  本文描述了用于治疗与TRPA1相关疾病的化合物和组合物。
• METHODS AND COMPOSITIONS FOR TREATING DISORDERS
  申请人：Ng Howard

  公开号：US20090143377A1

  公开（公告）日：2009-06-04

  Compounds and compositions for treating disorders related to TRPA1 are described herein.

  本文描述了用于治疗与TRPA1相关的疾病的化合物和组合物。