Methyl 4-[(naphthalen-2-ylsulfonylamino)methyl]benzoate | 471925-04-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Methyl 4-[(naphthalen-2-ylsulfonylamino)methyl]benzoate
• CAS: 471925-04-9
• 化学式: C₁₉H₁₇NO₄S
• 分子量: 355.414
• InChiKey: ORYOUNLJWSXSJK-UHFFFAOYSA-N

物化性质

• 沸点：
  562.3±60.0 °C(Predicted)
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 4-[(naphthalen-2-ylsulfonylamino)methyl]benzoate 在 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 4-(2-Naphthylsulfonamido)methylbenzoic acid
  参考文献：
  名称：

  Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

  摘要：

  Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00175-0
• 作为产物：
  描述：

  4-氨甲基苯甲酸甲酯盐酸盐 、 2-萘磺酰氯 以 二氯甲烷 为溶剂， 以70 %的产率得到Methyl 4-[(naphthalen-2-ylsulfonylamino)methyl]benzoate
  参考文献：
  名称：

  光敏剂可利用 UV-LED 和阳光形成联苯

  摘要：

  提出了一种通过光化学挤出无痕连接体（光拼接）来进行无金属联芳基合成的显着改进的方法。一系列醛和酮已被确定为强大的光敏剂，无需 UV−C 光，从而允许使用 UV LED 甚至阳光。这一进步不仅简化了反应装置，而且还实现了联苯的规模化生产。

  DOI：

  10.1002/chem.202400605

文献信息

• Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group
  作者：Shinichi Uesato、Manabu Kitagawa、Yasuo Nagaoka、Taishi Maeda、Hiroshi Kuwajima、Takao Yamori

  DOI：10.1016/s0960-894x(02)00175-0

  日期：2002.5

  Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Photosensitizers Enable the Formation of Biphenyls with UV‐LEDs and Sunlight
  作者：Veit G. Haensch、Christian Hertweck

  DOI：10.1002/chem.202400605

  日期：——

  A significantly improved method for metal-free biaryl synthesis through the photochemical extrusion of traceless linkers (photosplicing) is presented. An array of aldehydes and ketones have been identified as powerful photosensitizers that eliminate the requirement for UV−C light, allowing the use of UV LEDs and even sunlight. This advancement not only simplifies the reaction setup but also enables

  提出了一种通过光化学挤出无痕连接体（光拼接）来进行无金属联芳基合成的显着改进的方法。一系列醛和酮已被确定为强大的光敏剂，无需 UV−C 光，从而允许使用 UV LED 甚至阳光。这一进步不仅简化了反应装置，而且还实现了联苯的规模化生产。